중추신경흥분성 식욕억제제 사용의 부작용에 관한 신속 체계적 문헌고찰: 의존 및 정신병 중심으로

Abstract

Objectives: Although psychostimulants for suppressing appetite have indications for a short-term use, long-term prescriptions are also frequently encountered in clinical practice. The objective of this study was to overview the empirical evidence on the safety of such psychostimulants. Methods ： A rapid systematic review was conducted using existing systematic review articles or clinical guidelines developed by adopting systematic review methodology. Results ： Four systematic review articles or clinical guidelines were reviewed. Studies on the safety of diethylpropion were all short-term. Six case reports reported psychotic symptoms. Phentermine, phendimetrazine, and diethylpropion have been withdrawn in most countries due to their side effects such as drug abuse and cardiotoxicity. Long-term prescription safety for phentermine or diethylpropion was not addressed in existing clinical guidelines for pharmacological management of adult obesity. Moreover, studies on the efficacy and safety of psychostimulants in the childhood and adolescence obesity management have not been reported yet. Conclusion : The number of studies on the long-term safety of antiobesity psychostimulants prescriptions was too limited to conclude their efficacy and safety for long-term use. Thus, long-term prescriptions of antiobesity psychostimulants should be avoided and closer monitoring is needed even for short-term use of psychostimulants in subjects with mental health risk.