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Compared to serum triglyceride alone, the association between serum triglyceride to high-density lipoprotein cholesterol ratio and 10-year cardiovascular disease risk as determined by Framingham risk scores in a large Korean cohort

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dc.contributor.author김지혜-
dc.date.accessioned2022-09-14T01:31:09Z-
dc.date.available2022-09-14T01:31:09Z-
dc.date.issued2021-09-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190492-
dc.description.abstractBackground: The incidence of cardiovascular disease (CVD) has gradually increased to the extent that it has become the most common cause of mortality worldwide, and triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio, a surrogate marker of insulin resistance, has emerged as an independent predictor of CVD. Additionally, several recent studies have reported an independent association between triglyceride-rich lipoproteins and CVD risk. The present study was conducted to investigate the association between the CVD risk determined by the Framingham risk score and the TG alone and TG/HDL ratio in a large Korean cohort. Methods: This cross-sectional study included 6,995 participants aged 30 to 69 years that participated in a health examination program. TG/HDL ratio quartiles and TG quartiles were categorized as follows: Q1: ≤ 1.25, Q2: 1.26-2.07, Q3: 2.08-3.48, and Q4: ≥3.49; Q1: ≤ 71, Q2: 72-105, Q3: 106-159, and Q4: ≥160, respectively. Odds ratios (ORs) and 95% confidence intervals (CI) for high Framingham 10-year CVD risk (≥10%) were calculated across TG/HDL ratio quartiles and TG quartiles using multiple logistic regression analysis after adjusting for confounding variables. Results: The mean values of most cardiometabolic variables including body mass index, blood pressure, fasting plasma glucose levels, leukocyte count, median CRP levels, and Framingham 10-year CVD risk scores increased gradually with TG/HDL ratio quartiles. The OR (95% CI) of the highest TG/HDL ratio quartile and TG quartile as compared with the lowest TG/HDL ratio quartile and TG quartile for high Framingham 10-year CVD risk was 9.27 (6.68-12.86) and 0.97 (0.69-1.36) after adjusting for confounding variables, respectively. Conclusion: Compared to TG, the TG/HDL ratio was found to be positively and independently associated with Framingham 10-year CVD risk in a large Korean cohort.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCardiovascular Diseases* / epidemiology-
dc.subject.MESHCholesterol, HDL-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHHumans-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHTriglycerides-
dc.titleCompared to serum triglyceride alone, the association between serum triglyceride to high-density lipoprotein cholesterol ratio and 10-year cardiovascular disease risk as determined by Framingham risk scores in a large Korean cohort-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentDept. of Health Promotion (건강의학과)-
dc.contributor.googleauthorHyang-Rae Lee-
dc.contributor.googleauthorJong-Koo Kim-
dc.contributor.googleauthorJi-Hye Kim-
dc.contributor.googleauthorTae-Ha Chung-
dc.identifier.doi10.1016/j.cca.2021.05.029-
dc.contributor.localIdA05620-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid34058221-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0009898121001856-
dc.subject.keywordCardiovascular disease-
dc.subject.keywordInsulin resistance-
dc.subject.keywordTG-
dc.subject.keywordTG/HDL ratio-
dc.contributor.alternativeNameKim, Ji-Hye-
dc.contributor.affiliatedAuthor김지혜-
dc.citation.volume520-
dc.citation.startPage29-
dc.citation.endPage33-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.520 : 29-33, 2021-09-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers

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