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Assessment of primary prevention patients receiving an ICD - Systematic evaluation of ATP: APPRAISE ATP

Authors
 Claudio D Schuger  ;  Kenji Ando  ;  Daniel J Cantillon  ;  Pier D Lambiase  ;  Lluis Mont  ;  Bo Young Joung  ;  Darren Peress  ;  Patrick Yong  ;  Nicholas Wold  ;  James P Daubert 
Citation
 Heart Rhythm O2, Vol.2(4) : 405-411, 2021-08 
Journal Title
Heart Rhythm O2
Issue Date
2021-08
Keywords
ICD ; Primary prevention ; VT
Abstract
Background: The value of antitachycardia pacing (ATP) in the overall cohort of primary prevention patients who receive implantable cardioverter-defibrillators (ICDs) remains uncertain. ATP success reported in prior trials potentially included a large number of patients receiving unnecessary ATP for arrhythmias that may have self-terminated owing to the prematurity of the intervention. Although some patients derive benefit from initial ATP in terminating rapid ventricular arrhythmias and thereby preventing shocks, there are limited data allowing us to identify those patients a priori.

Objective: The purpose of APPRAISE ATP is to understand the role of ATP in primary prevention patients currently indicated for ICD therapy in a large prospective randomized controlled trial with modern programming parameters.

Methods: The study is a global, prospective, randomized, multicenter clinical trial conducted at up to 150 sites globally, enrolling approximately 2600 subjects The primary endpoint of the trial is time to first all-cause shock in a 2-arm study with an equivalent study design in which the incidence of all-cause shocks will be compared between primary prevention subjects programmed with shocks only vs subjects programmed to standard therapy (ATP and shock).

Results: An Electrogram and Device Interrogation Core Laboratory will review interrogation data to determine primary endpoints that occur in APPRAISE ATP. Their decisions are based on independent physician review of the data from device interrogation.

Conclusion: The ultimate purpose of the study is to aid clinicians in the selection of ICD technologies based on hard endpoint evidence across the spectrum of indications for primary prevention implantation.
Files in This Item:
T202126096.pdf Download
DOI
10.1016/j.hroo.2021.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190473
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