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Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study

 In-Jeong Cho  ;  Jeong-Hun Shin  ;  Mi-Hyang Jung  ;  Chae Young Kang  ;  Jinseub Hwang  ;  Chang Hee Kwon  ;  Woohyeun Kim  ;  Dae-Hee Kim  ;  Chan Joo Lee  ;  Si-Hyuck Kang  ;  Ju-Hee Lee  ;  Hack-Lyoung Kim  ;  Hyue Mee Kim  ;  Iksung Cho  ;  Hae-Young Lee  ;  Wook-Jin Chung  ;  Sang-Hyun Ihm  ;  Kwang Il Kim  ;  Eun Joo Cho  ;  Il-Suk Sohn  ;  Sungha Park  ;  Jinho Shin  ;  Sung Kee Ryu  ;  Jang Young Kim  ;  Seok-Min Kang  ;  Myeong-Chan Cho  ;  Wook Bum Pyun  ;  Ki-Chul Sung 
 JOURNAL OF CLINICAL MEDICINE, Vol.10(4) : 771, 2021-02 
Journal Title
Issue Date
antihypertensive agent ; cohort study ; neoplasms
We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
Cho, Ik Sung(조익성)
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