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The Association between Serum Hemoglobin and Renal Prognosis of IgA Nephropathy

Authors
 Tae Ryom Oh  ;  Su Hyun Song  ;  Hong Sang Choi  ;  Chang Seong Kim  ;  Seung Hyeok Han  ;  Kyung Pyo Kang  ;  Young Joo Kwon  ;  Soo Wan Kim  ;  Seong Kwon Ma  ;  Eun Hui Bae 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(2) : 363, 2021-01 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2021-01
Keywords
IgA nephropathy ; anemia ; disease progression ; glomerulonephritis ; hemoglobin ; prognosis ; risk factors
Abstract
Immunoglobin A (IgA) nephropathy causes chronic kidney disease worldwide. Therefore, identifying risk factors associated with the progression of IgA nephropathy is crucial. Anemia is a common complication of chronic kidney disease; however, few studies have investigated the effect of serum hemoglobin on the renal prognosis of IgA nephropathy. This study aimed to determine the effect of serum hemoglobin on the progression of IgA nephropathy. We retrospectively analyzed 4326 patients with biopsy-proven IgA nephropathy. We evaluated the effect of serum hemoglobin on IgA nephropathy progression using Kaplan-Meier survival analyses, the log-rank test, and the Cox proportional hazards model. The primary end-point was progression of IgA nephropathy, defined as dialysis initiation or kidney transplantation. Serum hemoglobin showed a nonlinear relationship with the progression of IgA nephropathy. The Cox proportional hazards model showed that the risk of progression of IgA nephropathy decreased 0.87 times for every 1.0 g/dL increase in serum hemoglobin. In subgroup analyses, reduced serum hemoglobin was an independent risk factor for IgA nephropathy progression only in women. There was no statistically significant interaction of serum hemoglobin between men and women (P interaction = 0.177). Results of Sensitivity analysis were robust and consistent. Serum hemoglobin at diagnosis was an independent predictor for IgA nephropathy progression.
Files in This Item:
T202125982.pdf Download
DOI
10.3390/jcm10020363
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190334
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