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Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes

Authors
 Jun Gyo Gwon  ;  Jimi Choi  ;  Cheol Woong Jung  ;  Chang Hun Lee  ;  Se Won Oh  ;  Sang-Kyung Jo  ;  Won Yong Cho  ;  Jae Berm Park  ;  Kyu Ha Huh  ;  Han Ro  ;  Seungyeup Han  ;  Jang-Hee Cho  ;  Sik Lee  ;  Jaeseok Yang  ;  Myung-Gyu Kim 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 783, 2021-01 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-01
MeSH
Adult ; Age Factors ; Body Mass Index* ; Cardiovascular Diseases / diagnosis* ; Cardiovascular Diseases / etiology ; Cohort Studies ; Diabetes Mellitus / physiopathology* ; Female ; Humans ; Kidney Transplantation / adverse effects* ; Longitudinal Studies ; Male ; Middle Aged ; Models, Statistical ; Risk Factors ; Waist-Hip Ratio*
Abstract
Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient's survival.
Files in This Item:
T202125976.pdf Download
DOI
10.1038/s41598-020-80266-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190330
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