Cited 24 times in
Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials
DC Field | Value | Language |
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dc.contributor.author | 이용제 | - |
dc.date.accessioned | 2022-09-14T01:10:49Z | - |
dc.date.available | 2022-09-14T01:10:49Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190324 | - |
dc.description.abstract | Background: Recent systematic reviews and meta-analyses of randomized, double-blind, placebo-controlled trials (double-blind, placebo-controlled RCTs) have reported controversial findings regarding the associations between calcium supplements on the risk of cardiovascular disease (CVD). This meta-analysis aimed to investigate the association between them. Methods: We searched PubMed, EMBASE, the Cochrane Library, and the bibliographies of relevant articles for double-blind, placebo-controlled RCTs in November, 2020. Relative risks (RRs) with 95% confidence intervals (CIs) for the risk of cardiovascular disease were calculated using a random effects model. The main outcomes were CVD, coronary heart disease (CHD), and cerebrovascular disease. Results: A total of 13 double-blind, placebo-controlled RCTs (n = 28,935 participants in an intervention group and 14,243 in a control group)) were included in the final analysis. Calcium supplements significantly increased the risk of CVD (RR 1.15, 95% CI 1.06-1.25], I2 = 0.0%, n = 14) and CHD (RR 1.16, 95% CI 1.05-1.28], I2 = 0.0%, n = 9) in double-blind, placebo-controlled RCTs, specifically in healthy postmenopausal women. In the subgroup meta-analysis, dietary calcium intake of 700-1000 mg per day or supplementary calcium intake of 1000 mg per day significantly increased the risk of CVD and CHD. Conclusions: The current meta-analysis found that calcium supplements increased a risk of CVD by about 15% in healthy postmenopausal women. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI Publishing | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Calcium / administration & dosage* | - |
dc.subject.MESH | Calcium, Dietary* | - |
dc.subject.MESH | Cardiovascular Diseases / prevention & control* | - |
dc.subject.MESH | Clinical Trials as Topic | - |
dc.subject.MESH | Coronary Disease | - |
dc.subject.MESH | Databases, Factual | - |
dc.subject.MESH | Dietary Supplements* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Eating | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Randomized Controlled Trials as Topic | - |
dc.title | Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Seung-Kwon Myung | - |
dc.contributor.googleauthor | Hong-Bae Kim | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Yoon-Jung Choi | - |
dc.contributor.googleauthor | Seung-Won Oh | - |
dc.identifier.doi | 10.3390/nu13020368 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J02396 | - |
dc.identifier.eissn | 2072-6643 | - |
dc.identifier.pmid | 33530332 | - |
dc.subject.keyword | calcium supplements | - |
dc.subject.keyword | cardiovascular disease | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | randomized controlled trials | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 368 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, Vol.13(2) : 368, 2021-01 | - |
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