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New approaches towards the discovery and evaluation of bioactive peptides from natural resources

Authors
 Nam Joo Kang  ;  Hyeon-Su Jin  ;  Sung-Eun Lee  ;  Hyun Jung Kim  ;  Hong Koh  ;  Dong-Woo Lee 
Citation
 CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY, Vol.50(1) : 72-103, 2020-01 
Journal Title
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
ISSN
 1064-3389 
Issue Date
2020-01
Keywords
Bioactive peptides ; hydrolysis ; informatics ; protease ; therapeutics
Abstract
Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition.
Full Text
https://www.tandfonline.com/doi/abs/10.1080/10643389.2019.1619376?journalCode=best20
DOI
10.1080/10643389.2019.1619376
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190323
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