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KMBARC registry: protocol for a multicentre observational cohort study on non-cystic fibrosis bronchiectasis in Korea

Authors
 Hyun Lee  ;  Hayoung Choi  ;  Yun Su Sim  ;  Shinhee Park  ;  Woo Jin Kim  ;  Kwang Ha Yoo  ;  Seung Jun Lee  ;  Tae-Hyung Kim  ;  Bumhee Yang  ;  Ina Jeong  ;  Soo-Jung Um  ;  Deog Kyeom Kim  ;  Ji-Hyun Lee  ;  Byoung Soo Kwon  ;  Young-Jae Cho  ;  Hye Yun Park  ;  Chang-Hoon Lee  ;  Chin Kook Rhee  ;  Sang Haak Lee  ;  Ju Ock Na  ;  An-Soo Jang  ;  Ji Ye Jung  ;  Seung Won Ra  ;  Ji-Ho Lee  ;  Sang-Ha Kim  ;  Changhwan Kim  ;  Youlim Kim  ;  Chang Youl Lee  ;  Hyun Kuk Kim  ;  Jae Seung Lee  ;  Sei Won Lee  ;  Yeon-Mok Oh 
Citation
 BMJ OPEN, Vol.10(1) : e034090, 2020-01 
Journal Title
BMJ OPEN
Issue Date
2020-01
MeSH
Adult ; Bronchiectasis / epidemiology ; Bronchiectasis / therapy* ; Cystic Fibrosis ; Disease Progression ; Female ; Follow-Up Studies ; Hospitalization / statistics & numerical data* ; Humans ; Male ; Middle Aged ; Morbidity / trends ; Prognosis ; Prospective Studies ; Quality of Life* ; Registries* ; Republic of Korea / epidemiology ; Surveys and Questionnaires
Keywords
bronchiectasis ; cohort study ; internal medicine
Abstract
Introduction Despite the significant disease burden of bronchiectasis in Korea, no large-scale, representative prospective cohort studies have been conducted to evaluate the clinical characteristics of Korean patients with bronchiectasis, indicating an urgent need for cohort studies on bronchiectasis. Methods and analysis The Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) is a prospective, non-interventional observational cohort study on bronchiectasis in Korea. The inclusion criteria of this registry are as follows: (1) adult patients (aged >= 18 years) with or without respiratory symptoms (cough, chronic sputum and/or recurrent respiratory infection) and chest computed tomography revealing bronchiectasis affecting one or more lobes and (2) stable status at the time of registration: patients with bronchiectasis who were admitted for a respiratory aetiology can be enrolled at least 4 weeks after hospital discharge. The exclusion criteria are as follows: (1) bronchiectasis due to cystic fibrosis; (2) traction bronchiectasis associated with interstitial lung disease; (3) patients actively being treated for pneumonia, pulmonary tuberculosis or non-tuberculous mycobacterial infection; (4) patients who are unable or unwilling to provide informed consent; and (5) pregnant patients. Although the KMBARC questionnaires for baseline and annual follow-up data are similar to the European Multicentre Bronchiectasis Audit and Research Collaboration questionnaires, KMBARC has distinctive features such as use of Bronchiectasis Health Questionnaires, measurement with fatigue and depression scales, blood tests, use of consensus definition of exacerbations and information on emergency room or hospitalisation. We aim to recruit at least 1200 patients over the study period from more than 26 hospitals in South Korea. Patients will undergo a detailed baseline and yearly assessment for up to 5 years. The study objectives of the KMBARC registry are as follows: (1) uncovering the natural course of bronchiectasis; (2) aiding in establishing evidence-based bronchiectasis guidelines in Korea; and (3) encouraging and facilitating studies on bronchiectasis in Korea. Ethics and dissemination This study received necessary approval from the Institutional Review Boards of all participating institutions. The Asan Medical Center Institutional Review Board gave overall approval for the study. Results will be disseminated via peer-reviewed publications and conference presentations.
Files in This Item:
T9992020525.pdf Download
DOI
10.1136/bmjopen-2019-034090
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190300
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