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Relationship between Cardiac Geometry and Serum Hepcidin in Chronic Kidney Disease: Analysis from the KNOW-CKD Study

 Hyang Ki Min  ;  Yun Kyu Oh  ;  Kyu Hun Choi  ;  Kyu Beck Lee  ;  Sue K Park  ;  Curie Ahn  ;  Sung Woo Lee 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.35(1) : e2, 2020-01 
Journal Title
Issue Date
Adult ; Aged ; Anemia / complications ; Echocardiography ; Female ; Heart Ventricles / anatomy & histology ; Heart Ventricles / physiopathology ; Hepcidins / blood* ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prospective Studies ; Renal Insufficiency, Chronic / diagnosis* ; Renal Insufficiency, Chronic / pathology ; Risk Factors ; Sex Factors ; Stroke Volume ; Transferrin / analysis ; Ventricular Function, Left / physiology*
Cardiac Geometry ; Relative Wall Thickness ; Hepcidin ; Erythropoietin Resistance ; Chronic Kidney Disease
Background: Few studies have examined the relationship between cardiac function and geometry and serum hepcidin levels in patients with chronic kidney disease (CKD). We aimed to identify the relationship between cardiac function and geometry and serum hepcidin levels. Methods: We reviewed data of 1,897 patients in a large-scale multicenter prospective Korean study. Logistic regression analysis was used to identify the relationship between cardiac function and geometry and serum hepcidin levels. Results: The mean relative wall thickness (RWT) and left ventricular mass index (LVMI) were 0.38 and 42.0 g/m(2.7), respectively. The mean ejection fraction (EF) and early diastolic mitral inflow to annulus velocity ratio (E/e') were 64.1% and 9.9, respectively. Although EF and E/e' were not associated with high serum hepcidin, RWT and LVMI were significantly associated with high serum hepcidin levels in univariate logistic regression analysis. In multivariate logistic regression analysis after adjusting for variables related to anemia, bone mineral metabolism, comorbidities, and inflammation, however, only each 0.1-unit increase in RWT was associated with increased odds of high serum hepcidin (odds ratio, 1.989; 95% confidence interval, 1.358-2.916; P < 0.001). In the subgroup analysis, the independent relationship between RWT and high serum hepcidin level was valid only in women and patients with low transferrin saturation (TSAT). Conclusion: Although the relationship was not cause-and-effect, increased RWT was independently associated with high serum hepcidin, particularly in women and patients with low TSAT. The relationship between cardiac geometry and serum hepcidin in CKD patients needs to be confirmed in future studies.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
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