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Immobilized DNA aptamers used as potent attractors for vascular endothelial cell: in vitro study of female rat

Authors
 Jung-Joon Cha  ;  Hoyeon Lee  ;  Miyoung Kim  ;  Juyoung Kang  ;  Hanlim Song  ;  Min-Gon Kim  ;  Jong-Hyun Lee 
Citation
 BIOSCIENCE REPORTS, Vol.40 : BSR20182444, 2020-01 
Journal Title
BIOSCIENCE REPORTS
ISSN
 0144-8463 
Issue Date
2020-01
MeSH
Animals ; Aptamers, Nucleotide / metabolism* ; Biomarkers / metabolism ; Carcinogenesis / metabolism ; Cardiovascular Diseases / metabolism ; Endothelial Cells / metabolism* ; Female ; Immobilized Nucleic Acids / metabolism* ; Ligands ; Rats
Abstract
Vascular endothelial cells are essential to vascular function and maintenance. Dysfunction of these cells can lead to the development of cardiovascular disease or contribute to tumorigenesis. As such, the therapeutic modulation and monitoring of vascular endothelial cells are of significant clinical interest, and several endothelial-specific ligands have been developed for drug delivery and the monitoring of endothelial function. However, the application of these ligands has been limited by their high cost and tendency to induce immune responses, highlighting a need for alternate methods of targeting vascular endothelial cells. In the present study, we explore the therapeutic potential of DNA aptamers. Using cell-SELEX technology, we identified two aptamers with specific binding affinity for vascular endothelial cells and propose that these molecules show potential for use as new ligands for drug and biomarker research concerning vascular endothelial cells.
Files in This Item:
T9992020499.pdf Download
DOI
10.1042/BSR20182444
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cha, Jung-Joon(차정준) ORCID logo https://orcid.org/0000-0002-8299-1877
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190274
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