Cited 52 times in
Rifabutin Is Active against Mycobacterium abscessus in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2022-09-06T06:41:57Z | - |
dc.date.available | 2022-09-06T06:41:57Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190271 | - |
dc.description.abstract | There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdc(scid)/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Society for Microbiology | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents / chemistry | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology* | - |
dc.subject.MESH | Clarithromycin / pharmacology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Repositioning | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Diseases / drug therapy* | - |
dc.subject.MESH | Lung Diseases / microbiology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred NOD | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous / drug therapy* | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous / microbiology | - |
dc.subject.MESH | Mycobacterium abscessus / drug effects* | - |
dc.subject.MESH | Rifabutin / chemistry | - |
dc.subject.MESH | Rifabutin / pharmacology* | - |
dc.title | Rifabutin Is Active against Mycobacterium abscessus in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Thomas Dick | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Won-Jung Koh | - |
dc.contributor.googleauthor | Véronique Dartois | - |
dc.contributor.googleauthor | Martin Gengenbacher | - |
dc.identifier.doi | 10.1128/AAC.01943-19 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J00189 | - |
dc.identifier.eissn | 1098-6596 | - |
dc.identifier.pmid | 31767722 | - |
dc.subject.keyword | nontuberculous mycobacteria | - |
dc.subject.keyword | NTM | - |
dc.subject.keyword | rifamycin | - |
dc.subject.keyword | mouse model | - |
dc.subject.keyword | animal model | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | 신성재 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e01943-19 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.64(2) : e01943-19, 2020-01 | - |
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