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Impact of stent generation on 2-year clinical outcomes in ST-segment elevation myocardial infarction patients with multivessel disease who underwent culprit-only or multivessel percutaneous coronary intervention

Authors
 Yong Hoon Kim  ;  Ae-Young Her  ;  Myung Ho Jeong  ;  Byeong-Keuk Kim  ;  Sung-Jin Hong  ;  Jung-Sun Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Myeong-Ki Hong  ;  Yangsoo Jang 
Citation
 CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol.95(2) : E40-E55, 2020-02 
Journal Title
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
ISSN
 1522-1946 
Issue Date
2020-02
MeSH
Aged ; Aged, 80 and over ; Cause of Death ; Coronary Artery Disease / diagnostic imaging ; Coronary Artery Disease / mortality ; Coronary Artery Disease / therapy* ; Coronary Thrombosis / etiology ; Drug-Eluting Stents ; Female ; Humans ; Male ; Metals ; Middle Aged ; Percutaneous Coronary Intervention / adverse effects ; Percutaneous Coronary Intervention / instrumentation* ; Percutaneous Coronary Intervention / mortality ; Prosthesis Design ; Recurrence ; Registries ; Republic of Korea ; Retrospective Studies ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction / diagnostic imaging ; ST Elevation Myocardial Infarction / therapy* ; Stents* ; Time Factors ; Treatment Outcome
Keywords
multivessel disease ; percutaneous coronary intervention ; stents ; ST-segment elevation myocardial infarction
Abstract
Background Data concerning the impact of stent generation on long-term outcomes in ST-segment elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) who underwent primary percutaneous coronary intervention (PCI) with culprit-only PCI (C-PCI) or multivessel PCI (M-PCI) are limited. Methods A total of 7,266 patients were separated into the two groups, a C-PCI (n = 4,901) or M-PCI group (n = 2,365). The primary endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction, and any repeat revascularization. The secondary endpoint was the cumulative incidence of stent thrombosis (ST) at 2 years. Results The cumulative incidence of MACE was significantly higher in the bare-metal stents (BMS) group than the first-generation (1G)-drug-eluting stents (DES) (C-PCI: adjusted hazard ratio [aHR], 1.940; 95% confidence interval [CI], 1.389-2.709; p < .001; M-PCI: aHR, 1.544; 95% CI, 1.099-2.074; p = .038), and the second-generation (2G)-DES group (C-PCI: aHR, 2.271; 95% CI, 1.657-3.114; p < .001; M-PCI: aHR, 2.999; 95% CI, 1.899-4.704; p < .001). In the M-PCI group, 1G-DES showed a higher incidence of MACE compared with 2G-DES (aHR, 1.639; 95% CI, 1.028-2.614; p = .004). The cumulative incidences of ST in the both groups were similar. Conclusion The cumulative incidence of MACE was the lowest for 2G-DES, the highest for BMS, and intermediate for 1G-DES in the STEMI patients with MVD after C-PCI or M-PCI. However, cumulative incidence of ST in the two different reperfusion strategy groups was similar regardless of stent generation.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/ccd.28440
DOI
10.1002/ccd.28440
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
Hong, Sung Jin(홍성진) ORCID logo https://orcid.org/0000-0003-4893-039X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190258
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