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Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus

 Kyung Soo Kim  ;  Seok Won Park  ;  Yong Wook Cho  ;  Soo Kyung Kim 
 Endocrinology and Metabolism (대한내분비학회지), Vol.35(1) : 97-105, 2020-03 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
Issue Date
Adult ; Biomarkers / blood* ; Diabetes, Gestational / physiopathology* ; Female ; Follow-Up Studies ; Glucose Intolerance / blood ; Glucose Intolerance / epidemiology* ; Glucose Intolerance / etiology ; Glucose Intolerance / pathology ; Humans ; Postpartum Period* ; Pregnancy ; Prevalence ; Prognosis ; Republic of Korea / epidemiology ; Risk Factors ; Vitamin D / analogs & derivatives* ; Vitamin D / blood ; Vitamin D Deficiency / complications*
Diabetes ; gestational ; Glucose intolerance ; Postpartum period ; Vitamin D deficiency
Background: To evaluate the association between sertun 25-hydroxyvitamin D (25(OH)D) at mid-pregnancy and postpartum glucose intolerance in women with gestational diabetes mellitus (GDM). Methods: We enrolled 348 pregnant women diagnosed with GDM from August 2012 to October 2016. We measured senim 25(OH) D levels at mid-pregnancy and carried out a 75-g oral glucose tolerance test at 6 to 12 weeks after delivery. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/mL. Results: The prevalence of vitamin D deficiency was 76.7% (n=267). Women with vitamin D deficiency had a higher prevalence of postpartum glucose intolerance than did those without vitamin D deficiency (48.7% vs. 32.1% P=0.011). Serum 25(OH)D level was negatively correlated with hemoglobin A1c at antepartum and postpartum period (antepartum: r=-0.186, P=0.001; postpartum: r=-0.129, P=0.047). Homeostasis model assessment of beta-cell function was positively correlated with senun 25(OH)D level only postpartum (r=0.138, P=0.035). The risk of postpartum glucose intolerance was 2.00 times (95% confidence interval, 1.13 to 3.55) higher in women with vitamin D deficiency than in those without vitamin D deficiency (P=0.018). Conclusion: In women with GDM, vitamin D deficiency at mid-pregnancy is associated with an elevated risk of postpartum glucose intolerance.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seok Won(박석원)
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