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Placental Site Plaque of the Uterine Cervix Misinterpreted as Low-Grade Squamous Intraepithelial Lesion in Liquid-Based Cervicovaginal Cytology: Usefulness of Inhibin-α Immunocytochemistry

Authors
 Hyunjin Kim  ;  Ha Young Woo  ;  Sang Hwa Lee  ;  Sung-Im Do  ;  Hyun-Soo Kim 
Citation
 CASE REPORTS IN ONCOLOGY, Vol.13(3) : 1415-1420, 2020-11 
Journal Title
CASE REPORTS IN ONCOLOGY
ISSN
 1662-6575 
Issue Date
2020-11
Keywords
Cervix ; Liquid-based cytology ; Low-grade squamous intraepithelial lesion ; Placental site plaque
Abstract
Cytological features of placental site plaques in liquid-based cervicovaginal preparations have been seldom documented in the literature. We present a rare case of endocervical placental site plaque misinterpreted as a low-grade squamous intraepithelial lesion in a liquid-based cytological preparation. A 32-year-old woman with polycystic ovarian syndrome gave birth 7 months previously. After delivery, she was diagnosed with cervical low-grade squamous intraepithelial lesion during routine cytological examination. Cytologically, many atypical cells showed large hyperchromatic nuclei with irregular membranes. The perinuclear cytoplasmic clearing closely resembled koilocytosis. Histologically, the endocervix showed typical histological features of a placental site plaque. Immunohistochemically, the trophoblasts were positive for p63, CD10, and inhibin-alpha but negative for p16. Based on genotyping, both the cytological and biopsied specimens tested negative for human papillomavirus. We re-examined the liquid-based preparation cytology slides thoroughly and concluded that the atypical cells initially misinterpreted as low-grade squamous intraepithelial lesion were actually trophoblasts. Immunocytochemical staining revealed uniform cytoplasmic inhibin-alpha expression in the trophoblasts. In summary, we demonstrated that endocervical placental site plaques can mimic low-grade squamous intraepithelial lesions in liquid-based cytological preparations. Immunocytochemical staining results and negative results on human papillomavirus genotyping further support that atypical cells resembling koilocytes are trophoblasts obtained from the placental site plaque.
Files in This Item:
T9992020163.pdf Download
DOI
10.1159/000510310
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Woo, Ha Young(우하영) ORCID logo https://orcid.org/0000-0002-3078-6484
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189942
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