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Phylogenetic Positioning of a Strongyloides stercoralis Isolate Recovered from a Korean Patient and Comparison with Other Asian Isolates

Authors
 Jaeho Bae  ;  Mi Jin Jeong  ;  Dong Hoon Shin  ;  Hyun Woo Kim  ;  Sung Ho Ahn  ;  Jun Ho Choi  ;  Hak Sun Yu 
Citation
 KOREAN JOURNAL OF PARASITOLOGY, Vol.58(6) : 689-694, 2020-12 
Journal Title
KOREAN JOURNAL OF PARASITOLOGY
ISSN
 0023-4001 
Issue Date
2020-12
MeSH
Animals ; Asia ; Asians ; DNA, Helminth / genetics ; DNA, Helminth / isolation & purification ; Humans ; Male ; Middle Aged ; Phylogeny* ; Sequence Analysis, DNA ; Strongyloides stercoralis / classification ; Strongyloides stercoralis / genetics* ; Strongyloides stercoralis / isolation & purification ; Strongyloidiasis / parasitology*
Keywords
Strongyloides stercoralis ; Strongyloidiasis ; Phylogenetic
Abstract
Strongyloidiasis is caused by Strongyloides stercoralis and is one of the most neglected tropical diseases in tropical and subtropical regions. Although several strongyloidiasis cases have been reported in Korea, genetic analysis of Korean isolates is still incomplete. In this study, a parasite was isolated from a 61-year-old man diagnosed with strongyloidiasis during the treatment of lymphoma on his retroperitoneal lymph node. Diffuse symmetric wall thickening from the ascending to descending colon and a nematode-infected intestine was observed following microscopic examination. Genomic DNA was isolated from a patient tissue block, and S. stercoralis was identified by PCR and sequencing (18S rDNA). In order to determine phylogenetic location of a Korean isolate (named KS1), we analyzed cox1 gene (500-bp) and compared it with that from 47 previous S. stercoralis isolates (28 human isolates and 19 canid isolates) from Asian countries. Our results showed that phylogenetic tree could clearly be divided into 5 different groups according to hosts and regions. KS1 was most closely related with the Chinese isolates in terms of genetic distance.
Files in This Item:
T9992020137.pdf Download
DOI
10.3347/kjp.2020.58.6.689
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Jun Ho(최준호) ORCID logo https://orcid.org/0000-0002-7416-3377
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189918
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