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Updates on the ketogenic diet therapy for pediatric epilepsy

Authors
 Ara Ko  ;  Hye Eun Kwon  ;  Heung Dong Kim 
Citation
 BIOMEDICAL JOURNAL, Vol.45(1) : 19-26, 2022-02 
Journal Title
BIOMEDICAL JOURNAL
ISSN
 2319-4170 
Issue Date
2022-02
MeSH
Child ; Diet, High-Fat ; Diet, Ketogenic* ; Drug Resistant Epilepsy* ; Epilepsy* ; Humans ; Ketone Bodies ; Treatment Outcome
Keywords
Epilepsy ; Ketogenic diet ; Pediatric
Abstract
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet, in which fat, instead of glucose, acts as a major energy source through the production of ketone bodies. The KD was formally introduced in 1921 to mimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatric epilepsy in the mid-1990s. Recent clinical and scientific knowledge supports the use of the KD in drug-resistant epilepsy patients for its anti-seizure efficacy, safety, and tolerability. The KD is also receiving growing attention as a potential treatment option for other neurological disorders. This article will review on the recent updates on the KD, focusing on its mechanisms of action, its alternatives, expansion on its use in terms of age groups and different regions in the world, and future issues.
Files in This Item:
T202203018.pdf Download
DOI
10.1016/j.bj.2021.11.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189575
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