Cited 11 times in
Association of Longitudinal Trajectories of Insulin Resistance With Adverse Renal Outcomes
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2022-08-23T00:40:18Z | - |
dc.date.available | 2022-08-23T00:40:18Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189557 | - |
dc.description.abstract | Objective: To analyze the relationship between time-serial changes in insulin resistance and renal outcomes. Research design and methods: A prospective cohort of subjects from the general population without chronic kidney disease (CKD) underwent a biennial checkup for 12 years (n = 5,347). The 12-year duration was divided into a 6-year exposure period, where distinct HOMA for insulin resistance (HOMA-IR) trajectories were identified using latent variable mixture modeling, followed by a 6-year event accrual period, from which the renal outcome data were analyzed. The primary end point was adverse renal outcomes, defined as a composite of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 in two or more consecutive checkups or albumin ≥1+ on urine strip. Results: Two distinct groups of HOMA-IR trajectories were identified during the exposure period: stable (n = 4,770) and increasing (n = 577). During the event accrual period, 449 patients (8.4%) developed adverse renal outcomes, and the risk was higher in the increasing HOMA-IR trajectory group than in the stable group (hazard ratio 2.06, 95% CI 1.62-2.60, P < 0.001). The results were similar after adjustment for baseline clinical characteristics, comorbidities, anthropometric and laboratory findings, eGFR, and HOMA-IR. The clinical significance of increasing HOMA-IR trajectory was similar in three or four HOMA-IR trajectories. The increasing tendency of HOMA-IR was persistently associated with a higher incidence of adverse renal outcomes, irrespective of the prevalence of diabetes. Conclusions: An increasing tendency of insulin resistance was associated with a higher risk of adverse renal outcomes. Time-serial tracking of insulin resistance may help identify patients at high risk for CKD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isPartOf | DIABETES CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / complications | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / epidemiology | - |
dc.title | Association of Longitudinal Trajectories of Insulin Resistance With Adverse Renal Outcomes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seokhun Yang | - |
dc.contributor.googleauthor | Soongu Kwak | - |
dc.contributor.googleauthor | You-Hyun Song | - |
dc.contributor.googleauthor | Seung Seok Han | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.contributor.googleauthor | Seung-Pyo Lee | - |
dc.identifier.doi | 10.2337/dc21-2521 | - |
dc.contributor.localId | A00052 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00721 | - |
dc.identifier.eissn | 1935-5548 | - |
dc.identifier.pmid | 35290429 | - |
dc.identifier.url | https://diabetesjournals.org/care/article/45/5/1268/144829/Association-of-Longitudinal-Trajectories-of | - |
dc.contributor.alternativeName | Kang, Shin Ae | - |
dc.contributor.affiliatedAuthor | 강신애 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1268 | - |
dc.citation.endPage | 1275 | - |
dc.identifier.bibliographicCitation | DIABETES CARE, Vol.45(5) : 1268-1275, 2022-05 | - |
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