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Mast4 determines the cell fate of MSCs for bone and cartilage development

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dc.contributor.author이동준-
dc.contributor.author정한성-
dc.contributor.author김현이-
dc.date.accessioned2022-08-23T00:32:15Z-
dc.date.available2022-08-23T00:32:15Z-
dc.date.issued2022-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189484-
dc.description.abstractMesenchymal stromal cells (MSCs) differentiation into different lineages is precisely controlled by signaling pathways. Given that protein kinases play a crucial role in signal transduction, here we show that Microtubule Associated Serine/Threonine Kinase Family Member 4 (Mast4) serves as an important mediator of TGF-β and Wnt signal transduction in regulating chondro-osteogenic differentiation of MSCs. Suppression of Mast4 by TGF-β1 led to increased Sox9 stability by blocking Mast4-induced Sox9 serine 494 phosphorylation and subsequent proteasomal degradation, ultimately enhancing chondrogenesis of MSCs. On the other hand, Mast4 protein, which stability was enhanced by Wnt-mediated inhibition of GSK-3β and subsequent Smurf1 recruitment, promoted β-catenin nuclear localization and Runx2 activity, increasing osteogenesis of MSCs. Consistently, Mast4-/- mice demonstrated excessive cartilage synthesis, while exhibiting osteoporotic phenotype. Interestingly, Mast4 depletion in MSCs facilitated cartilage formation and regeneration in vivo. Altogether, our findings uncover essential roles of Mast4 in determining the fate of MSC development into cartilage or bone.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCartilage / metabolism-
dc.subject.MESHCell Differentiation / genetics-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChondrogenesis-
dc.subject.MESHGlycogen Synthase Kinase 3 beta / metabolism-
dc.subject.MESHMesenchymal Stem Cells* / metabolism-
dc.subject.MESHMice-
dc.subject.MESHMicrotubule-Associated Proteins / metabolism*-
dc.subject.MESHOsteogenesis* / genetics-
dc.subject.MESHProtein Serine-Threonine Kinases / metabolism*-
dc.subject.MESHSerine / metabolism-
dc.subject.MESHWnt Signaling Pathway-
dc.titleMast4 determines the cell fate of MSCs for bone and cartilage development-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorPyunggang Kim-
dc.contributor.googleauthorJinah Park-
dc.contributor.googleauthorDong-Joon Lee-
dc.contributor.googleauthorSeiya Mizuno-
dc.contributor.googleauthorMasahiro Shinohara-
dc.contributor.googleauthorChang Pyo Hong-
dc.contributor.googleauthorYealeen Jeong-
dc.contributor.googleauthorRebecca Yun-
dc.contributor.googleauthorHyeyeon Park-
dc.contributor.googleauthorSujin Park-
dc.contributor.googleauthorKyung-Min Yang-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorSeung Pil Jang-
dc.contributor.googleauthorHyun-Yi Kim-
dc.contributor.googleauthorSeung-Jun Lee-
dc.contributor.googleauthorSun U Song-
dc.contributor.googleauthorKyung-Soon Park-
dc.contributor.googleauthorMikako Tanaka-
dc.contributor.googleauthorHayato Ohshima-
dc.contributor.googleauthorJin Won Cho-
dc.contributor.googleauthorFumihiro Sugiyama-
dc.contributor.googleauthorSatoru Takahashi-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorSeong-Jin Kim-
dc.identifier.doi10.1038/s41467-022-31697-3-
dc.contributor.localIdA02732-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid35803931-
dc.contributor.alternativeNameLee, Dong Joon-
dc.contributor.affiliatedAuthor이동준-
dc.contributor.affiliatedAuthor정한성-
dc.citation.volume13-
dc.citation.number1-
dc.citation.startPage3960-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.13(1) : 3960, 2022-07-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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