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Quenching Epigenetic Drug Resistance Using Antihypoxic Microparticles in Glioblastoma Patient-Derived Chips

DC Field Value Language
dc.contributor.author강석구-
dc.contributor.author성학준-
dc.contributor.author신영민-
dc.contributor.author이용재-
dc.contributor.author유승은-
dc.contributor.author윤선진-
dc.date.accessioned2022-08-23T00:13:24Z-
dc.date.available2022-08-23T00:13:24Z-
dc.date.issued2022-04-
dc.identifier.issn2192-2640-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189318-
dc.description.abstractGlioblastoma (GBM) is one of the most intractable tumor types due to the progressive drug resistance upon tumor mass expansion. Incremental hypoxia inside the growing tumor mass drives epigenetic drug resistance by activating nongenetic repair of antiapoptotic DNA, which could be impaired by drug treatment. Hence, rescuing intertumor hypoxia by oxygen-generating microparticles may promote susceptibility to antitumor drugs. Moreover, a tumor-on-a-chip model enables user-specified alternation of clinic-derived samples. This study utilizes patient-derived glioblastoma tissue to generate cell spheroids with size variations in a 3D microchannel network chip (GBM chip). As the spheroid size increases, epigenetic drug resistance is promoted with inward hypoxia severance, as supported by the spheroid size-proportional expression of hypoxia-inducible factor-1a in the chip. Loading antihypoxia microparticles onto the spheroid surface significantly reduces drug resistance by silencing the expression of critical epigenetic factor, resulting in significantly decreased cell invasiveness. The results are confirmed in vitro using cell line and patient samples in the chip as well as chip implantation into a hypoxic hindlimb ischemia model in mice, which is an unprecedented approach in the field.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfADVANCED HEALTHCARE MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHBrain Neoplasms* / pathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDrug Resistance-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHGlioblastoma* / drug therapy-
dc.subject.MESHGlioblastoma* / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia-
dc.subject.MESHMice-
dc.titleQuenching Epigenetic Drug Resistance Using Antihypoxic Microparticles in Glioblastoma Patient-Derived Chips-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorSewoom Baek-
dc.contributor.googleauthorSeung Eun Yu-
dc.contributor.googleauthorYu-Heng Deng-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorDong Gue Lee-
dc.contributor.googleauthorSurim Kim-
dc.contributor.googleauthorSeonjin Yoon-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorJeongeun Park-
dc.contributor.googleauthorChan Hee Lee-
dc.contributor.googleauthorJung Bok Lee-
dc.contributor.googleauthorHyun Joon Kong-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1002/adhm.202102226-
dc.contributor.localIdA00036-
dc.contributor.localIdA01958-
dc.contributor.localIdA05925-
dc.contributor.localIdA05165-
dc.relation.journalcodeJ00042-
dc.identifier.eissn2192-2659-
dc.identifier.pmid34963195-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/adhm.202102226-
dc.subject.keyword3D glioblastoma chip-
dc.subject.keyworddrug resistance-
dc.subject.keywordepigenetic alterations-
dc.subject.keywordhypoxia rescue-
dc.subject.keywordoxygen-releasing microparticles-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthor강석구-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor신영민-
dc.contributor.affiliatedAuthor이용재-
dc.citation.volume11-
dc.citation.number8-
dc.citation.startPagee2102226-
dc.identifier.bibliographicCitationADVANCED HEALTHCARE MATERIALS, Vol.11(8) : e2102226, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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