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Predictive Performance of CAGE-B and SAGE-B Models in Asian Treatment-Naive Patients Who Started Entecavir for Chronic Hepatitis B

Authors
 Hye Yeon Chon  ;  Jae Seung Lee  ;  Hye Won Lee  ;  Ho Soo Chun  ;  Beom Kyung Kim  ;  Won Young Tak  ;  Jun Yong Park  ;  Young-Oh Kweon  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Se Young Jang  ;  Soo Young Park  ;  Seung Up Kim 
Citation
 CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol.20(4) : e794-e807, 2022-04 
Journal Title
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 1542-3565 
Issue Date
2022-04
MeSH
Antiviral Agents / therapeutic use ; Carcinoma, Hepatocellular* / etiology ; Guanine / analogs & derivatives ; Hepatitis B, Chronic* / complications ; Hepatitis B, Chronic* / drug therapy ; Hepatitis B, Chronic* / pathology ; Humans ; Liver Cirrhosis / complications ; Liver Neoplasms* / etiology
Keywords
CAGE-B ; Chronic Hepatitis B ; Hepatocellular Carcinoma ; Risk Prediction Model ; SAGE-B
Abstract
Background & aims: Cirrhosis and age (CAGE-B) and stiffness and age (SAGE-B) models assess the risk of hepatocellular carcinoma (HCC) development in white patients with chronic hepatitis B (CHB) undergoing sustained antiviral therapy (AVT). Herein, we checked the predictive performance of these models in Asian patients with CHB.

Methods: We reviewed 734 treatment-naive patients with CHB who started entecavir between 2006 and 2011 and were followed up for more than 5 years without HCC development during AVT. The predictive performance of CAGE-B and SAGE-B models was calculated using area under the receiver operating characteristic curves (AUROCs).

Results: Median liver stiffness assessed using transient elastography after 5 years of AVT was 6.8 kPa. Median CAGE-B and SAGE-B models after 5 years of AVT were 7.0 and 6.0, respectively. More than 5 years after AVT initiation, 66 patients (9.0%) developed HCC. The AUROCs of the CAGE-B and SAGE-B models were 0.764 and 0.785 after 7 years and 0.799 and 0.802 after 10 years of AVT, respectively. The cumulative incidence of HCC was significantly higher in the high-risk groups according to CAGE-B and SAGE-B risk stratification than in the medium- and low-risk groups (P < .05 in all cases). The SAGE-B model showed a higher likelihood ratio (χ2) (76.2 vs 71.4) and linear trend (χ2) (74.1 vs 58.6) than the CAGE-B model, whereas the CAGE-B model showed higher Akaike information criteria (64.3 vs 50.3).

Conclusions: Both SAGE-B and CAGE-B showed acceptable performance in predicting HCC after 5 years of AVT in Asian patients with CHB.
Full Text
https://www.sciencedirect.com/science/article/pii/S1542356521006042?via%3Dihub
DOI
10.1016/j.cgh.2021.06.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Jae Seung(이재승) ORCID logo https://orcid.org/0000-0002-2371-0967
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
Chun, Ho Soo(전호수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189315
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