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Association Between C-Reactive Protein and Relative Handgrip Strength in Postmenopausal Korean Women Aged 45-80 Years: A Cross-Sectional Study

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dc.contributor.author손다혜-
dc.contributor.author이용제-
dc.date.accessioned2022-08-23T00:10:14Z-
dc.date.available2022-08-23T00:10:14Z-
dc.date.issued2022-06-
dc.identifier.issn1176-9092-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189293-
dc.description.abstractBackground: Chronic inflammation plays a key role in the pathophysiology of frailty and loss of physical performance, which are closely associated with sarcopenia. In women, the decline in muscle mass and strength is accelerated after menopause. Thus, we examined the association between high sensitivity C-reactive protein (hs-CRP) and relative handgrip strength (HGS) in postmenopausal women. Methods: This cross-sectional study included 2171 postmenopausal women aged ≥45 years who participated in the Korean National Health and Nutrition Survey (KNHNES) between 2015 and 2018. Relative HGS was categorized into quartiles as follows: Q1, <0.810 (kg/BMI); Q2, 0.810-0.968 (kg/BMI); Q3, 0.969-1.119 (kg/BMI); Q4, >1.119 (kg/BMI). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for high hs-CRP (>1.0 mg/L, 75 percentile of the current samples) were calculated across relative HGS quartiles using multiple logistic regression analysis. Results: The prevalence of high hs-CRP decreased with relative HGS quartiles. Compared to the highest quartile, the OR (95% CI) of the lowest relative HGS quartile for high hs-CRP was 3.266 (2.227-4.789) after adjusting for age, hypertension, diabetes mellitus, dyslipidemia, education, household income, physical activity, strength exercise, smoking, and alcohol ingestion. Conclusion: Serum hs-CRP level was inversely and independently associated with relative HGS. Our findings indicate that low-grade inflammation is inversely associated with muscle strength in postmenopausal women.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherDove Medical Press-
dc.relation.isPartOfCLINICAL INTERVENTIONS IN AGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHC-Reactive Protein* / analysis-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHand Strength* / physiology-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHPostmenopause-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.titleAssociation Between C-Reactive Protein and Relative Handgrip Strength in Postmenopausal Korean Women Aged 45-80 Years: A Cross-Sectional Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorDa-Hye Son-
dc.contributor.googleauthorSeung-Ah Song-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.2147/CIA.S356947-
dc.contributor.localIdA05543-
dc.contributor.localIdA02982-
dc.relation.journalcodeJ00582-
dc.identifier.eissn1178-1998-
dc.identifier.pmid35747693-
dc.subject.keywordC-reactive protein-
dc.subject.keywordhand strength-
dc.subject.keywordinflammation-
dc.subject.keywordmenopause-
dc.subject.keywordsarcopenia-
dc.contributor.alternativeNameSon, Da‐Hye-
dc.contributor.affiliatedAuthor손다혜-
dc.contributor.affiliatedAuthor이용제-
dc.citation.volume17-
dc.citation.startPage971-
dc.citation.endPage978-
dc.identifier.bibliographicCitationCLINICAL INTERVENTIONS IN AGING, Vol.17 : 971-978, 2022-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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