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Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans

DC Field Value Language
dc.contributor.author박병진-
dc.contributor.author이용제-
dc.contributor.author정동혁-
dc.date.accessioned2022-08-23T00:10:08Z-
dc.date.available2022-08-23T00:10:08Z-
dc.date.issued2022-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189292-
dc.description.abstractHDL cholesterol, besides its function in lipid metabolism, plays a role in suppressing blood oxidation reactions and protecting vascular endothelial cells. The uric acid/HDL cholesterol ratio (UHR) has recently attracted attention as a new biomarker for evaluating interactions between inflammatory and anti-inflammatory substances in the blood. This study aimed to investigate the longitudinal association between UHR and incident ischemic heart disease (IHD). Data from 16,455 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) were assessed. Over 50 months after baseline enrolment, 321 (2.0%) participants developed IHD. The HRs of incident IHD were 0.85 (95% CI, 0.55-1.29), 1.42 (95% CI, 0.94-2.13), and 1.57 (95% CI, 1.01-2.45) in the second, third, and fourth UHR quartiles, respectively, after adjusting for potential confounding variables. In the subgroup analysis by sex-specific quartile, women tended to have higher HRs in the highest UHR quartile. We found that high UHR values were positively associated with incident IHD in Koreans without diabetes. An increased UHR may be a useful measure by which to assess cardiovascular risk in the preclinical stage.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfBIOMEDICINES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePredictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorByoungjin Park-
dc.contributor.googleauthorDong-Hyuk Jung-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.3390/biomedicines10061422-
dc.contributor.localIdA01477-
dc.contributor.localIdA02982-
dc.contributor.localIdA03595-
dc.relation.journalcodeJ03914-
dc.identifier.eissn2227-9059-
dc.identifier.pmid35740443-
dc.subject.keywordKoreans-
dc.subject.keywordcohort study-
dc.subject.keywordischemic heart disease-
dc.subject.keyworduric acid to HDL cholesterol ratio-
dc.contributor.alternativeNamePark, Byoung Jin-
dc.contributor.affiliatedAuthor박병진-
dc.contributor.affiliatedAuthor이용제-
dc.contributor.affiliatedAuthor정동혁-
dc.citation.volume10-
dc.citation.number6-
dc.citation.startPage1422-
dc.identifier.bibliographicCitationBIOMEDICINES, Vol.10(6) : 1422, 2022-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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