Cited 2 times in
Diminished food-related motivation in adult rats treated with methamphetamine during adolescence
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2022-08-19T06:28:28Z | - |
dc.date.available | 2022-08-19T06:28:28Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189204 | - |
dc.description.abstract | Drug use among adolescents continues to be an area of concern because of the possibility of long-lasting physical and mental changes. The aim of this study was to determine whether methamphetamine exposure during adolescence results in long-lasting neurobehavioral alterations in adulthood. Sprague-Dawley rats were injected with methamphetamine (4 mg/kg/ day) during postnatal days 28-37. Once rats reached postnatal days 150, they were placed in standard operant chambers, where they were trained to respond to a lever for sucrose pellets, the experimental reinforcement. Methamphetamine exposure during adolescence did not result in a noteworthy impairment in the development of the correct lever touch response in the autoshaped learning test with 4 seconds delayed reinforcement. These rats were also tested for the motivation to obtain sucrose pellets under a progressive ratio schedule of the reinforcement on postnatal days 170. Decreased lever-pressing response was noted in male rats exposed to methamphetamine during adolescence, but not in female rats. These results indicate that methamphetamine exposure during adolescence results in a decrease in the motivation for a natural reinforcer later in adulthood, particularly in male rats. From our data, we suggest that male brains are less capable of facilitating recovery than female brains after methamphetamine-induced perturbation of brain function during the adolescent period. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Central Nervous System Stimulants / toxicity* | - |
dc.subject.MESH | Feeding Behavior / drug effects* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methamphetamine / toxicity* | - |
dc.subject.MESH | Motivation / drug effects* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Time | - |
dc.title | Diminished food-related motivation in adult rats treated with methamphetamine during adolescence | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Jung Ho Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.identifier.doi | 10.1097/WNR.0000000000001325 | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 31568209 | - |
dc.subject.keyword | adolescent | - |
dc.subject.keyword | autoshaping | - |
dc.subject.keyword | methamphetamine | - |
dc.subject.keyword | motivation | - |
dc.subject.keyword | progressive fixed ratio | - |
dc.subject.keyword | sex | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | 김동구 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1143 | - |
dc.citation.endPage | 1147 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.30(17) : 1143-1147, 2019-12 | - |
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