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Eight-week healing of grafted calvarial bone defects with hyperbaric oxygen therapy in rats

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dc.contributor.author허경석-
dc.date.accessioned2022-08-19T06:26:59Z-
dc.date.available2022-08-19T06:26:59Z-
dc.date.issued2019-08-
dc.identifier.issn2093-2278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189182-
dc.description.abstractPurpose: The purpose of this study was to evaluate the synergistic effect of adjunctive hyperbaric oxygen (HBO) therapy on new bone formation and angiogenesis after 8 weeks of healing. Methods: Sprague-Dawley rats (n=28) were split into 2 groups according to the application of adjunctive HBO therapy: a group that received HBO therapy (HBO group [n=14]) and another group that did not receive HBO therapy (NHBO group [n=14]). Each group was divided into 2 subgroups according to the type of bone graft material: a biphasic calcium phosphate (BCP) subgroup and an Escherichia roll-derived recombinant human bone morphogenetic protein-2-/epigallocatechin-3-gallate-coated BCP (mBCP) subgroup. Two identical circular defects with a 6-mm diameter were made in the right and left parietal bones of each rat. One defect was grafted with bone graft material (BCP or mBCP). The other defect was not grafted. The HBO group received 2 weeks of adjunctive HBO therapy (1 hour, 5 times a week). The rats were euthanized 8 weeks after surgery. The specimens were prepared for histologic analysis. Results: New bone (%) was higher in the NHBO-mBCP group than in the NHBO-BCP and control groups (P<0.05). Blood vessel count (%) and vascular endothelial growth factor staining (%) were higher in the HBO-mBCP group than in the NHBO-mBCP group (p<0.05). Conclusions: HBO therapy did not have a positive influence on bone formation irrespective of the type of bone graft material applied after 8 weeks of healing. HBO therapy had a positive effect on angiogenic activity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Academy of Periodontology-
dc.relation.isPartOfJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEight-week healing of grafted calvarial bone defects with hyperbaric oxygen therapy in rats-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorSeo-Eun Oh-
dc.contributor.googleauthorKyung-Seok Hu-
dc.contributor.googleauthorSungtae Kim-
dc.identifier.doi10.5051/jpis.2019.49.4.228-
dc.contributor.localIdA04342-
dc.relation.journalcodeJ01695-
dc.identifier.eissn2093-2286-
dc.identifier.pmid31485373-
dc.subject.keywordBone substitute-
dc.subject.keywordBiphasic calcium phosphate-
dc.subject.keywordEpigallocatechin-3-gallate-
dc.subject.keywordBone morphogenetic protein 2-
dc.subject.keywordHyperbaric oxygen therapy-
dc.contributor.alternativeNameHu, Kyung Seok-
dc.contributor.affiliatedAuthor허경석-
dc.citation.volume49-
dc.citation.number4-
dc.citation.startPage228-
dc.citation.endPage236-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.49(4) : 228-236, 2019-08-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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