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Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies

Authors
 Theo H van der Kwast  ;  Jozien Helleman  ;  Daan Nieboer  ;  Sophie M Bruinsma  ;  Monique J Roobol  ;  Bruce Trock  ;  Behfar Ehdaie  ;  Peter Carroll  ;  Christopher Filson  ;  Jeri Kim  ;  Christopher Logothetis  ;  Todd Morgan  ;  Laurence Klotz  ;  Tom Pickles  ;  Eric Hyndman  ;  Caroline M Moore  ;  Vincent Gnanapragasam  ;  Mieke Van Hemelrijck  ;  Prokar Dasgupta  ;  Chris Bangma  ;  Monique Roobol  ;  Arnauld Villers  ;  Antti Rannikko  ;  Riccardo Valdagni  ;  Antoinette Perry  ;  Jonas Hugosson  ;  Jose Rubio-Briones  ;  Anders Bjartell  ;  Lukas Hefermehl  ;  Lee Lui Shiong  ;  Mark Frydenberg  ;  Yoshiyuki Kakehi  ;  Byung Ha Chung  ;  Theo van der Kwast  ;  Henk Obbink  ;  Wim van der Linden  ;  Tim Hulsen  ;  Cees de Jonge  ;  Mike Kattan  ;  Ji Xinge  ;  Kenneth Muir  ;  Artitaya Lophatananon  ;  Michael Fahey  ;  Ewout Steyerberg  ;  Daan Nieboer  ;  Liying Zhang  ;  Wei Guo  ;  Nicole Benfante  ;  Janet Cowan  ;  Dattatraya Patil  ;  Emily Tolosa  ;  Tae-Kyung Kim  ;  Alexandre Mamedov  ;  Vincent LaPointe  ;  Trafford Crump  ;  Jenna Kimberly-Duffell  ;  Aida Santaolalla  ;  Daan Nieboer  ;  Jona-Than Olivier  ;  Tiziana Rancati  ;  Helén Ahlgren  ;  Juanma Mascarós  ;  Annica Löfgren  ;  Kurt Lehmann  ;  Catherine Han Lin  ;  Hiromi Hirama  ;  Kwang Suk Lee  ;  Guido Jenster  ;  Anssi Auvinen  ;  Anders Bjartell  ;  Masoom Haider  ;  Kees van Bochove  ;  Ballentine Carter  ;  Sam Gledhill  ;  Mark Buzza  ;  Chris Bangma  ;  Monique Roobol  ;  Sophie Bruinsma  ;  Jozien Helleman 
Citation
 EUROPEAN UROLOGY ONCOLOGY, Vol.2(3) : 333-336, 2019-05 
Journal Title
EUROPEAN UROLOGY ONCOLOGY
Issue Date
2019-05
MeSH
Biopsy / standards ; Biopsy / statistics & numerical data ; Humans ; Male ; Neoplasm Grading ; Prostatic Neoplasms / pathology* ; Quality of Health Care ; Watchful Waiting / organization & administration ; Watchful Waiting / standards* ; Watchful Waiting / statistics & numerical data
Keywords
Prostate cancer ; Active surveillance ; GAP3 consortium ; Pathology review ; Biopsy quality ; Gleason grading
Abstract
Within the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative, 25 centers across the globe collaborate to standardize active surveillance (AS) protocols for men with low-risk prostate cancer (PCa). A centralized PCa AS database, comprising data of more than 15 000 patients worldwide, was created. Comparability of the histopathology between the different cohorts was assessed by a centralized pathology review of 445 biopsies from 15 GAP3 centers. Grade group 1 (Gleason score 6) in 85% and grade group >= 2 (Gleason score >= 7) in 15% showed 89% concordance at review with moderate agreement (kappa = 0.56). Average biopsy core length was similar among the analyzed cohorts. Recently established highly adverse pathologies, including cribriform and/or intraductal carcinoma, were observed in 3.6% of the reviewed biopsies. In conclusion, the centralized pathology review of 445 biopsies revealed comparable histopathology among the 15 GAP3 centers with a low frequency of high-risk features. This enables further data analyses-without correction-toward uniform global AS guidelines for men with low-risk PCa. Patient summary: Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative combines data from 15 000 men with low-risk prostate cancer (PCa) across the globe to standardize active surveillance protocols. Histopathology review confirmed that the histopathology was consistent with low-risk PCa in most men and comparable between different centers. Crown Copyright (C) 2018 Published by Elsevier B.V. on behalf of European Association of Urology. All rights reserved.
Full Text
https://www.sciencedirect.com/science/article/pii/S2588931118301366
DOI
10.1016/j.euo.2018.08.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189142
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