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Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

Authors
 Woo-Suk Lee  ;  Hwan Jin Kim  ;  Kang-Il Kim  ;  Gi Beom Kim  ;  Wook Jin 
Citation
 STEM CELLS TRANSLATIONAL MEDICINE, Vol.8(6) : 504-511, 2019-06 
Journal Title
STEM CELLS TRANSLATIONAL MEDICINE
ISSN
 2157-6564 
Issue Date
2019-06
MeSH
Adipose Tissue / cytology ; Aged ; Cartilage, Articular / diagnostic imaging ; Double-Blind Method ; Female ; Humans ; Injections, Intra-Articular ; Magnetic Resonance Imaging ; Male ; Mesenchymal Stem Cell Transplantation* / adverse effects ; Mesenchymal Stem Cells / cytology ; Mesenchymal Stem Cells / metabolism ; Middle Aged ; Osteoarthritis, Knee / pathology ; Osteoarthritis, Knee / therapy* ; Placebo Effect ; Transplantation, Autologous ; Treatment Outcome
Keywords
Adipose-derived mesenchymal stem cell ; Intra-articular injection ; Knee ; Osteoarthritis
Abstract
Mesenchymal stem cells (MSCs) have been the focus of an emerging treatment for osteoarthritis. However, few studies reported about outcomes of an intra-articular injection of autologous adipose-derived mesenchymal stem cells (AD-MSCs). This study aimed to assess the efficacy and safety of a single intra-articular injection of AD-MSCs for patients with knee osteoarthritis. It was a prospective double-blinded, randomized controlled, phase IIb clinical trial. AD-MSCs were administered for 12 patients (MSC group), and the group was compared with 12 knees with injection of normal saline (control group) up to 6 months. All procedures were performed in the outpatient clinic. Primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score. Secondary outcome measure included various clinical and radiologic examination, and safety after injection. Change of cartilage defect after injection was evaluated using magnetic resonance imaging (MRI). Single injection of AD-MSCs led to a significant improvement of the WOMAC score at 6 months. In the control group, there was no significant change in the WOMAC score at 6 months. No serious adverse events were observed in both groups during the follow-up period. In MRI, there was no significant change of cartilage defect at 6 months in MSC group whereas the defect in the control group was increased. An intra-articular injection of autologous AD-MSCs provided satisfactory functional improvement and pain relief for patients with knee osteoarthritis in the outpatient setting, without causing adverse events at 6 months' follow-up. Larger sample size and long-term follow-up are required.
Files in This Item:
T201906661.pdf Download
DOI
10.1002/sctm.18-0122
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189004
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