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Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study

Authors
 Jin Yong Lee  ;  Yuri Cho  ;  Min Hee Hong  ;  Jayeun Kim  ;  Dong Hyeon Lee  ;  Yong Jin Jung  ;  Byeong Gwan Kim  ;  Kook Lae Lee  ;  Won Kim 
Citation
 Gastroenterology & Hepatology, Vol.34(4) : 747-754, 2019-04 
Journal Title
Gastroenterology & Hepatology
ISSN
 1554-7914 
Issue Date
2019-04
MeSH
Age Factors ; Female ; Hepatitis, Alcoholic / epidemiology* ; Hepatitis, Alcoholic / mortality* ; Hospital Mortality* ; Hospitalization / statistics & numerical data* ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Patient Readmission / statistics & numerical data* ; Republic of Korea / epidemiology ; Sex Factors ; Social Class ; Time Factors
Keywords
alcoholic hepatitis ; hospitalization ; incidence ; mortality ; readmission
Abstract
Background and aim: Alcoholic hepatitis (AH) ranks among the most costly diseases in South Korea. However, accurate hospitalization incidence rates, mortality rates, and contributing factors have not been investigated in South Korea. This study aimed to provide the nationwide incidence of hospitalization, inhospital mortality, and readmission rates for South Korean patients with AH.

Methods: Using the Korean Health Insurance Review and Assessment service database, a total of 39 800 inpatient cases from 2008 to 2012 were identified based on the International Classification of Diseases, 10th Revision diagnosis code for AH (K70.1). Standardized hospitalization incidence and mortality rates were calculated, and logistic regression analysis was performed to identify risk factors for inhospital mortality and readmission. Follow-up data for those admitted in 2008 were collected to assess readmissions.

Results: The standardized incidence rate for AH hospitalization per 105 person/year decreased from 19 in 2008 to 14 in 2012 (P = 0.001). The annual inhospital mortality rate ranged from 0.2% to 0.5%. Inhospital mortality was significantly higher in older patients (odds ratio [OR], 1.36) and those with cirrhosis (OR, 4.40). The readmission rate for patients admitted in 2008 was 34.0%. Male sex (OR, 1.21) and low economic status (OR, 2.35) were significantly associated with readmission, whereas older age (OR, 0.96), cirrhosis (OR, 0.77), and urban residency (OR, 0.68) were inversely associated with readmission.

Conclusions: This study captured a 5-year epidemiologic period in South Korea of patients with AH to reflect the real burden of AH and to provide valuable information to policy-makers assessing public health priorities.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/jgh.14513
DOI
10.1111/jgh.14513
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Min Hee(홍민희) ORCID logo https://orcid.org/0000-0003-3490-2195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188983
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