Cited 3 times in
Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus
DC Field | Value | Language |
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dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2022-08-16T08:24:19Z | - |
dc.date.available | 2022-08-16T08:24:19Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 2035-909X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188970 | - |
dc.description.abstract | Purpose Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy with febrile seizure plus (GEFS+) are still unclear. Therefore we perform this study to find the association of promotor variants in pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) genes and anti-inflammatory cytokine interleukin 10 (IL-10) genes either with FS, FS+, and GEFS+ in Korean children. Methods Fifty-seven children with FS, 32 FS+, and 12 GEFS+ patients were compared with 108 controls. The allelic and genotypic distributions were compared for TNF-α-238 (rs361525), -308 (rs1800629), -857 (rs1799724), -863 (rs1800630), and IL-10-592 (rs1800872), -819 (rs1800871), -1082 (rs1800896), and -1352 (rs1800893). Results Allelic and genotypic frequencies of TNF-α and IL-10 promotor variants showed no significant differences between FS, FS+, and GEFS+ versus controls. However, AA genotypes at TNF-α-863 were present only in controls. TNF-α-863 (rs1800630) promoter variants showed an association with FS, FS+, and GEFS+ in a recessive mode of inheritance pattern (P<0.05). Conclusion Our results suggest that AA genotypes at TNF-α-863 may be associated with FS, FS+, and GEFS+, implicating protective roles against to development of FS, FS+, and GEFS+. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Child Neurology Society | - |
dc.relation.isPartOf | Annals of Child Neurology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Jieun Choi | - |
dc.contributor.googleauthor | Sun Ah Choi | - |
dc.contributor.googleauthor | Soo Yeon Kim | - |
dc.contributor.googleauthor | Hunmin Kim | - |
dc.contributor.googleauthor | Byung Chan Lim | - |
dc.contributor.googleauthor | Hee Hwang | - |
dc.contributor.googleauthor | Jong Hee Chae | - |
dc.contributor.googleauthor | Ki Joong Kim | - |
dc.contributor.googleauthor | Sohee Oh | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.identifier.doi | 10.26815/acn.2019.00038 | - |
dc.contributor.localId | A02144 | - |
dc.relation.journalcode | J03965 | - |
dc.identifier.eissn | 2635-9103 | - |
dc.subject.keyword | Tumor necrosis factor-alpha | - |
dc.subject.keyword | Interleukin-10 | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Seizures, febrile | - |
dc.subject.keyword | Variants | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | 신전수 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Annals of Child Neurology, Vol.27(2) : 38-45, 2019-05 | - |
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