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Prognostic Factors for Absence Epilepsy in Childhood

 So Young Kang  ;  Chung Mo Koo  ;  Se Hee Kim  ;  Heung Dong Kim  ;  Joon Soo Lee  ;  Hoon-Chul Kang 
 Annals of Child Neurology, Vol.27(3) : 71-75, 2019-09 
Journal Title
Annals of Child Neurology
Issue Date
Epilepsy, absence ; Comorbidity ; Prognosis
Purpose: Childhood absence epilepsy (CAE) is a common form of idiopathic generalized epilepsy
with onset middle childhood and has typically a good prognosis, but remission rates vary. We
aimed to analyze unfavorable prognostic factors in children initially diagnosed with CAE.
Methods: We retrospectively reviewed 48 patients under 13 years of age who were diagnosed
with CAE at the Severance Children’s Hospital, Seoul, Korea. We analyzed clinical information in cluding comorbidity through neuropsychological test.
Results: Thirteen of the 48 patients (27%) showed an unfavorable prognosis, with clinical sei zures or seizure waves on electroencephalogram persistent even after 12 months of anticonvul sant therapy. The mean age at absence seizure onset was 6.51±2.36 years. The most commonly
used antiepileptic drug (AED) was ethosuximide, and the median duration of initial AEDs was
25.63±24.41 months. The presence of comorbidity and clinical absence seizures after 6 months
of AEDs correlated with an unfavorable prognosis. Motor seizures were the most unfavorable
prognostic factor during follow-up.
Conclusion: This study shows that clinical absence seizures after 6 months of AED, comorbidity,
and motor seizure are the most important predictive factors of an unfavorable prognosis for ab sence epilepsy in childhood. This study suggests that when these factors are observed, early in tervention needs to be considered.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Koo, Chung Mo(구청모)
Kim, Se Hee(김세희) ORCID logo https://orcid.org/0000-0001-7773-1942
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
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