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Sex-Related Reserve Hypothesis in Alzheimer's Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up

Authors
 Juyoun Lee  ;  Hanna Cho  ;  Seun Jeon  ;  Hee Jin Kim  ;  Yeo Jin Kim  ;  Jeongmin Lee  ;  Sung Tae Kim  ;  Jong-Min Lee  ;  Juhee Chin  ;  Samuel N Lockhart  ;  Ae Young Lee  ;  Duk L Na  ;  Sang Won Seo 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.65(2) : 641-649, 2018 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2018
MeSH
Aged ; Alzheimer Disease / diagnostic imaging* ; Alzheimer Disease / physiopathology ; Cerebral Cortex / diagnostic imaging* ; Cerebral Cortex / pathology ; Cerebral Cortex / physiopathology ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Image Interpretation, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Models, Neurological ; Organ Size ; Prospective Studies ; Sex Characteristics*
Keywords
Alzheimer’s disease ; cognitive reserve ; cortical thickness ; longitudinal study ; sex
Abstract
Background: Sex effects on the progression of Alzheimer's disease (AD) have received less attention than other demographic factors, including onset age and education.

Objective: The aim of this study was to investigate whether sex affected cortical thinning in the disease progression of AD.

Methods: We prospectively recruited 36 patients with early-stage AD and 14 people with normal cognition. All subjects were assessed with magnetic resonance imaging at baseline, Year 1, Year 3, and Year 5. We performed cortical thickness analyses using surface-based morphometry on magnetic resonance imaging.

Results: Women with AD showed more rapid cortical thinning in the left dorsolateral frontal cortex, left superior temporal gyrus, bilateral temporo-parietal association cortices, bilateral anterior cingulate gyri, bilateral medial frontal cortices, and bilateral occipital cortices over 5 years than men with AD, even though there was no difference in cortical thickness at baseline. In contrast, there were no regions of significantly more rapid atrophy in men with AD.

Conclusions: Our findings suggest that women deteriorate faster than men in the progression of AD.
Files in This Item:
T999201818.pdf Download
DOI
10.3233/JAD-180049
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188926
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