Cited 10 times in
Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | 지종현 | - |
dc.contributor.author | 강혜영 | - |
dc.contributor.author | 남보영 | - |
dc.contributor.author | 정수영 | - |
dc.contributor.author | 박서현 | - |
dc.contributor.author | 김형래 | - |
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 기연경 | - |
dc.contributor.author | 윤창연 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2022-08-16T01:30:34Z | - |
dc.date.available | 2022-08-16T01:30:34Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1434-6621 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188903 | - |
dc.description.abstract | Background: Soluble CD89 (sCD89)-IgA complex plays a key role in the pathogenesis of IgA nephropathy (IgAN). However, there is a lack of evidence supporting this complex as a good biomarker for disease progression. This study aimed to evaluate the usefulness of sCD89-IgA complex for risk stratification of IgAN. Methods: A total of 326 patients with biopsy-proven IgAN were included. sCD89-IgA complex was measured by sandwich-enzyme-linked immunosorbent assay. The study endpoints were a 30% decline in estimated glomerular filtration rate (eGFR). Results: sCD89-IgA complex levels were inversely and weakly associated with eGFR at the time of biopsy (r=-0.12, p=0.03). However, the significance between the two factors was lost in the multivariate linear regression after adjustment of clinical factors (β=0.35, p=0.75). In a multivariate Cox model, the highest (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.35-1.61; p=0.45) and middle (HR, 0.93; 95% CI, 0.46-1.89; p=0.84) tertiles of sCD89-IgA complex levels were not associated with an increased risk of developing a 30% decrease in eGFR. Furthermore, the decline rates in eGFR did not differ between groups and C-statistics revealed that the sCD89-IgA complex were not superior to clinical factors in predicting disease progression. Conclusions: This study found no association between sCD89-IgA complex levels and disease progression in IgAN. Although sCD89 can contribute to the formation of immune complexes, our findings suggest that the sCD89-IgA level is not a good predictor of adverse outcomes and has limited clinical utility as a biomarker for risk stratification in IgAN. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Walter De Gruyter | - |
dc.relation.isPartOf | CLINICAL CHEMISTRY AND LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antigens, CD / blood* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Glomerulonephritis, IGA / blood* | - |
dc.subject.MESH | Glomerulonephritis, IGA / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin A / blood* | - |
dc.subject.MESH | Kidney Function Tests | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Receptors, Fc / blood* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Hye-Young Kang | - |
dc.contributor.googleauthor | Meiyan Wu | - |
dc.contributor.googleauthor | Bo Young Nam | - |
dc.contributor.googleauthor | Tae-Ik Chang | - |
dc.contributor.googleauthor | Su-Young Jung | - |
dc.contributor.googleauthor | Seohyun Park | - |
dc.contributor.googleauthor | Hyoungnae Kim | - |
dc.contributor.googleauthor | Hae-Ryong Yun | - |
dc.contributor.googleauthor | Youn Kyung Kee | - |
dc.contributor.googleauthor | Chang-Yun Yoon | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1515/cclm-2017-0090 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A00096 | - |
dc.contributor.localId | A01251 | - |
dc.contributor.localId | A04667 | - |
dc.contributor.localId | A01495 | - |
dc.contributor.localId | A01147 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A00276 | - |
dc.contributor.localId | A02613 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J00567 | - |
dc.identifier.eissn | 1437-4331 | - |
dc.identifier.pmid | 28672768 | - |
dc.identifier.url | https://www.degruyter.com/document/doi/10.1515/cclm-2017-0090/html | - |
dc.subject.keyword | CD89 | - |
dc.subject.keyword | IgA nephropathy | - |
dc.subject.keyword | estimated glomerular filtration rate (eGFR) | - |
dc.contributor.alternativeName | Jhee, Jong Hyun | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 강혜영 | - |
dc.contributor.affiliatedAuthor | 남보영 | - |
dc.contributor.affiliatedAuthor | 정수영 | - |
dc.contributor.affiliatedAuthor | 박서현 | - |
dc.contributor.affiliatedAuthor | 김형래 | - |
dc.contributor.affiliatedAuthor | 윤해룡 | - |
dc.contributor.affiliatedAuthor | 기연경 | - |
dc.contributor.affiliatedAuthor | 윤창연 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.56(1) : 75-85, 2018-01 | - |
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