75 212

Cited 9 times in

Longitudinal follow-up study of the association between statin use and chronic periodontitis using national health screening cohort of Korean population

Authors
 Mi Jung Kwon  ;  Soo-Hwan Byun  ;  Joo-Hee Kim  ;  Ji Hee Kim  ;  Se Hoon Kim  ;  Nan Young Kim  ;  Hye-Rim Park  ;  Hyo Geun Choi 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 5504, 2022-04 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-04
MeSH
Adult ; Chronic Periodontitis* / epidemiology ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors* / adverse effects ; Male ; Republic of Korea / epidemiology
Abstract
Since a potential link between statins and the risk of adverse chronic periodontitis (CP) has been raised, we aimed to validate the association between statin use and the incidence of CP using nationwide cohort data. This longitudinal follow-up study included 169,381 patients prescribed statins who were matched with an equal number of controls using propensity scores from the Korean National Health Insurance Service-Health Screening Cohort database (2002-2015). A Cox proportional hazard model was used to assess the occurrence of CP following statin use after adjusting for multiple covariates. The occurrence of CP was significantly higher in patients who had long-term use (1-3 years, 3-5 years, or > 5 years) than with short-term use (≤ 1 year) of statins. After adjustment, statin users exhibited an occurrence of CP 1.32-fold higher (95% confidence interval 1.30-1.33) than that of the matched nonusers (incidence: 25.0 and 22.0 per 100 person-years, respectively). Subgroup analyses supported the adverse impact of statins on CP independent of age and gender. Statin user odds ratios for developing CP were higher compared to those of nonusers. This was consistent in individuals aged > 40 years in both genders, especially with long-term use.
Files in This Item:
T202201519.pdf Download
DOI
10.1038/s41598-022-09540-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188851
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links