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Vasodilatory Effect of Alpinia officinarum Extract in Rat Mesenteric Arteries

 Chae Eun Haam  ;  Seonhee Byeon  ;  Soo Jung Choi  ;  Soyeon Lim  ;  Soo-Kyoung Choi  ;  Young-Ho Lee 
 MOLECULES, Vol.27(9) : 2711, 2022-04 
Journal Title
Issue Date
Alpinia* ; Animals ; Endothelium, Vascular ; Eucalyptol / pharmacology ; Mesenteric Arteries ; Plant Extracts / pharmacology ; Rats ; Vasodilation*
Alpinia officinarum ; Ca2+ ; eucalyptol ; mesenteric resistance arteries ; relaxation ; vasodilation.
Background: Alpinia officinarum (A. officinarum) is known to exhibit a beneficial effect for anti-inflammatory, anti-oxidant, and anti-hyperlipidemic effects. However, no sufficient research data are available on the cardiovascular effect of A. officinarum. Thus, in this study, we investigate whether A. officinarum extract has direct effects on vascular reactivity.

Methods: To examine whether A. officinarum extract affects vascular functionality, we measured isometric tension in rat mesenteric resistance arteries using a wire myograph. After arteries were pre-contracted with high-K+ (70 mM), phenylephrine (5 µM), or U46619 (1 µM), A. officinarum extract was treated.

Results: A. officinarum extract induced vasodilation in a concentration-dependent manner, and this effect was endothelium independent. To further investigate the mechanism, we incubated arteries in a Ca2+-free and high-K+ solution, followed by the cumulative addition of CaCl2 (0.01-2.5 mM) with or without A. officinarum extract (30 µg/mL). Pre-treatment of A. officinarum extract reduced the contractile responses induced by cumulative administration of Ca2+, which suggests that extracellular Ca2+ influx was inhibited by the treatment of A. officinarum extract. These results were associated with a reduction in phosphorylated MLC20 in VSMCs treated with A. officinarum extract. Furthermore, eucalyptol, an active compound of A. officinarum extract, had a similar effect as A. officinarum extract, which causes vasodilation in mesenteric resistance arteries.

Conclusion: A. officinarum extract and its active compound eucalyptol induce concentration-dependent vasodilation in mesenteric resistance arteries. These results suggest that administration of A. officinarum extract could exert beneficial effects to treat high blood pressure.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Byeon, Seon Hee(변선희) ORCID logo https://orcid.org/0000-0001-9256-5209
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Choi, Soo Kyoung(최수경) ORCID logo https://orcid.org/0000-0002-7115-6358
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