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Direct Contact with Platelets Induces Podoplanin Expression and Invasion in Human Oral Squamous Cell Carcinoma Cells

DC Field Value Language
dc.contributor.author송나영-
dc.contributor.author임미화-
dc.contributor.author장향란-
dc.contributor.author정원윤-
dc.contributor.author조은애산드라-
dc.contributor.author이선경-
dc.date.accessioned2022-07-08T03:22:43Z-
dc.date.available2022-07-08T03:22:43Z-
dc.date.issued2022-05-
dc.identifier.issn1976-9148-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188817-
dc.description.abstractOral squamous cell carcinoma (OSCC) is mostly diagnosed at an advanced stage, with local and/or distal metastasis. Thus, locoregional and/or local control of the primary tumor is crucial for a better prognosis in patients with OSCC. Platelets have long been considered major players in cancer metastasis. Traditional antiplatelet agents, such as aspirin, are thought to be potential chemotherapeutics, but they need to be used with caution because of the increased bleeding risk. Podoplanin (PDPN)-expressing cancer cells can activate platelets and promote OSCC metastasis. However, the reciprocal effect of platelets on PDPN expression in OSCC has not been investigated. In this study, we found that direct contact with platelets upregulated PDPN and integrin β1 at the protein level and promoted invasiveness of human OSCC Ca9.22 cells that express low levels of PDPN. In another human OSCC HSC3 cell line that express PDPN at an abundant level, silencing of the PDPN gene reduced cell invasiveness. Analysis of the public database further supported the co-expression of PDPN and integrin β1 and their increased expression in metastatic tissues compared to normal and tumor tissues of the oral cavity. Taken together, these data suggest that PDPN is a potential target to regulate platelet-tumor interaction and metastasis for OSCC treatment, which can overcome the limitations of traditional antiplatelet drugs.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Applied Pharmacology-
dc.relation.isPartOfBIOMOLECULES & THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDirect Contact with Platelets Induces Podoplanin Expression and Invasion in Human Oral Squamous Cell Carcinoma Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorSe-Young Park-
dc.contributor.googleauthorSun Kyoung Lee-
dc.contributor.googleauthorMihwa Lim-
dc.contributor.googleauthorBomi Kim-
dc.contributor.googleauthorByeong-Oh Hwang-
dc.contributor.googleauthorEunae Sandra Cho-
dc.contributor.googleauthorXianglan Zhang-
dc.contributor.googleauthorKyung-Soo Chun-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorNa-Young Song-
dc.identifier.doi10.4062/biomolther.2021.167-
dc.contributor.localIdA05713-
dc.contributor.localIdA03362-
dc.contributor.localIdA03489-
dc.contributor.localIdA03676-
dc.contributor.localIdA04799-
dc.relation.journalcodeJ00324-
dc.identifier.eissn2005-4483-
dc.identifier.pmid35110423-
dc.subject.keywordDirect contact-
dc.subject.keywordMetastasis-
dc.subject.keywordOral cancer-
dc.subject.keywordPlatelets-
dc.subject.keywordPodoplanin-
dc.contributor.alternativeNameSong, Na-Young-
dc.contributor.affiliatedAuthor송나영-
dc.contributor.affiliatedAuthor임미화-
dc.contributor.affiliatedAuthor장향란-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor조은애산드라-
dc.citation.volume30-
dc.citation.number3-
dc.citation.startPage284-
dc.citation.endPage290-
dc.identifier.bibliographicCitationBIOMOLECULES & THERAPEUTICS, Vol.30(3) : 284-290, 2022-05-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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