Cited 3 times in
Anti-atrial Fibrillation Effects of Pulmonary Vein Isolation With or Without Ablation Gaps: A Computational Modeling Study
DC Field | Value | Language |
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dc.contributor.author | 진제 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박제욱 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 유희태 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 임병현 | - |
dc.contributor.author | 권오석 | - |
dc.date.accessioned | 2022-07-08T03:20:16Z | - |
dc.date.available | 2022-07-08T03:20:16Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188795 | - |
dc.description.abstract | Background: Although pulmonary vein isolation (PVI) gaps contribute to recurrence after atrial fibrillation (AF) catheter ablation, the mechanism is unclear. We used realistic computational human AF modeling to explore the AF wave-dynamic changes of PVI with gaps (PVI-gaps). Methods: We included 40 patients (80% male, 61.0 ± 9.8 years old, 92.5% persistent AF) who underwent AF catheter ablation to develop our realistic computational AF model. We compared the effects of a complete PVI (CPVI) and PVI-gap (2-mm × 4) on the AF wave-dynamics by evaluating the dominant frequency (DF), spatial change of DF, maximal slope of the action potential duration restitution curve (Smax), and AF defragmentation rate (termination or change to atrial tachycardia), and tested the effects of additional virtual interventions and flecainide on ongoing AF with PVI-gaps. Results: Compared with the baseline AF, CPVIs significantly reduced extra-PV DFs (p < 0.001), but PVI-gaps did not. COV-DFs were greater after CPVIs than PVI-gaps (p < 0.001). Neither CPVIs nor PVI-gaps changed the mean Smax. CPVIs resulted in higher AF defragmentation rates (80%) than PVI-gaps (12.5%, p < 0.001). In ongoing AF after PVI-gaps, the AF defragmentation rates after a wave-breaking gap ablation, extra-PV DF ablation, or flecainide were 60.0, 34.3, and 25.7%, respectively (p = 0.010). Conclusion: CPVIs effectively reduced the DF, increased its spatial heterogeneity in extra-PV areas, and offered better anti-AF effects than extra-PV DF ablation or additional flecainide in PVI-gap conditions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Anti-atrial Fibrillation Effects of Pulmonary Vein Isolation With or Without Ablation Gaps: A Computational Modeling Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ze Jin | - |
dc.contributor.googleauthor | Inseok Hwang | - |
dc.contributor.googleauthor | Byounghyun Lim | - |
dc.contributor.googleauthor | Oh-Seok Kwon | - |
dc.contributor.googleauthor | Je-Wook Park | - |
dc.contributor.googleauthor | Hee-Tae Yu | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.3389/fphys.2022.846620 | - |
dc.contributor.localId | A06196 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A04574 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02868 | - |
dc.identifier.eissn | 1664-042X | - |
dc.identifier.pmid | 35370797 | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | computational modeling | - |
dc.subject.keyword | dominant frequency | - |
dc.subject.keyword | gap | - |
dc.subject.keyword | pulmonary vein | - |
dc.contributor.alternativeName | Jin, Ze | - |
dc.contributor.affiliatedAuthor | 진제 | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 박제욱 | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 846620 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHYSIOLOGY, Vol.13 : 846620, 2022-03 | - |
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