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Serum Low-Density Lipoprotein Cholesterol Levels and Depressive Mood in Korean Adults: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.date.accessioned | 2022-07-08T03:18:31Z | - |
dc.date.available | 2022-07-08T03:18:31Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188775 | - |
dc.description.abstract | Background: The association between serum cholesterol levels and depression has been studied extensively; however, results are inconsistent. This study aimed to investigate the association between low-density lipoprotein cholesterol (LDL-C) levels and depressive symptoms among Korean adults. Methods: This cross-sectional study used data obtained from the 2007-2015 Korea National Health and Nutrition Examination Survey. In total, 40,904 adults were included in the final analysis. Participants were categorized into five groups according to their LDL-C levels, using the Korean guidelines for dyslipidemia. Symptoms of depression were evaluated using a self-reported questionnaire. Weighted logistic regression was used to examine the relationship between LDL-C levels and self-reported depressive symptoms. Results: Compared with the intermediate category, the lowest (<70 mg/dL) and highest (≥160 mg/dL) LDL-C categories were associated with depressive symptoms, after adjusting for potential confounding factors (odds ratio [OR], 1.191; 95% confidence interval [CI], 1.008-1.409; OR, 1.241; 95% CI, 1.073-1.435, respectively). The highest LDL-C category was positively associated with depressive symptoms in those who were middle-aged, female, had a low body mass index, and taking or not taking dyslipidemia medications. Conclusion: A U-shaped association was identified between LDL-C categories and self-reported depressive symptoms. Our findings suggest that LDL-C levels that are too low or too high are associated with self-reported depressive symptoms. Further prospective studies are needed to determine the causal relationship of this association. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한가정의학회 | - |
dc.relation.isPartOf | Korean Journal of Family Medicine(가정의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum Low-Density Lipoprotein Cholesterol Levels and Depressive Mood in Korean Adults: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Seog-Young Jo | - |
dc.contributor.googleauthor | Yu-Jin Kwon | - |
dc.contributor.googleauthor | A-Ra Cho | - |
dc.identifier.doi | 10.4082/kjfm.21.0102 | - |
dc.contributor.localId | A04882 | - |
dc.relation.journalcode | J02007 | - |
dc.identifier.eissn | 2092-6715 | - |
dc.identifier.pmid | 35130641 | - |
dc.subject.keyword | Cholesterol | - |
dc.subject.keyword | Depression | - |
dc.subject.keyword | Lipids | - |
dc.subject.keyword | Low-Density Lipoprotein | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | 권유진 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 68 | - |
dc.identifier.bibliographicCitation | Korean Journal of Family Medicine (가정의학회지), Vol.43(1) : 63-68, 2022-01 | - |
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