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Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case-control study using nationwide data

Authors
 Jeong Eun Shin  ;  Haerin Jang  ;  Jung Ho Han  ;  Joonsik Park  ;  Soo Yeon Kim  ;  Yoon Hee Kim  ;  Ho Seon Eun  ;  Soon Min Lee  ;  Kook In Park  ;  Myung Hyun Sohn  ;  Min Soo Park  ;  Kyung Won Kim 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 7578, 2022-05 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-05
MeSH
Adolescent ; Adult ; Asthma* / complications ; Asthma* / epidemiology ; Bronchopulmonary Dysplasia* / complications ; Bronchopulmonary Dysplasia* / epidemiology ; Case-Control Studies ; Child ; Child, Preschool ; Humans ; Infant, Newborn ; Morbidity ; Respiratory Distress Syndrome, Newborn* / complications ; Respiratory Distress Syndrome, Newborn* / epidemiology ; Risk Factors ; Young Adult
Abstract
Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the association of BPD on childhood lower respiratory illness (LRI) and asthma among patients diagnosed with respiratory distress syndrome (RDS). This case-control study analyzed data between 2002 and 2015 from a nationwide database. We included 55,066 children with RDS. Two-year LRI and asthma at ages 3 and 5 were assessed. Readmission for LRIs within 2 years of birth occurred in 53.9% and 37.9% of the BPD (n = 9470) and non-BPD (n = 45,596) cases, respectively. In the BPD group, the median number of hospitalizations, mechanical ventilation and oxygen use rates were significantly higher, while the hospitalization duration was significantly longer (P < 0.001 for all). The relative risk of BPD was 1.42 (1.39-1.45) on total readmission and 6.53 (5.96-7.15) on intensive care unit readmission. Asthma prevalence was significantly higher in BPD group (57.6% vs. 48.9% at age 3 and 44.3% vs. 38.2% at age 5, P < 0.001). In children with RDS, BPD could affect repetitive and worse LRI as an independent risk factor for respiratory morbidity during the first 2 years of life. BPD may also be a crucial risk factor for asthma in preschoolers.
Files in This Item:
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DOI
10.1038/s41598-022-11657-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Soo Yeon(김수연) ORCID logo https://orcid.org/0000-0003-4965-6193
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Park, Joon Sik(박준식) ORCID logo https://orcid.org/0000-0002-4902-4770
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Han, Jung Ho(한정호) ORCID logo https://orcid.org/0000-0001-6661-8127
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188769
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