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Association of Alzheimer's Disease with COVID-19 Susceptibility and Severe Complications: A Nationwide Cohort Study

Authors
 Seok Jong Chung  ;  Yoonkyung Chang  ;  Jimin Jeon  ;  Jae Il Shin  ;  Tae-Jin Song  ;  Jinkwon Kim 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.87(2) : 701-710, 2022-05 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2022-05
MeSH
Alzheimer Disease* / epidemiology ; COVID-19* / complications ; Cohort Studies ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Keywords
Alzheimer disease ; COVID-19 ; mortality ; prognosis ; susceptibility
Abstract
Background: Identification of patients at high susceptibility and high risk of developing serious complications related to coronavirus disease 2019 (COVID-19) infection is clinically important in the face of the COVID-19 pandemic.

Objective: To investigate whether patients with Alzheimer's disease (AD) are more susceptible to COVID-19 infection and whether they have a higher risk of developing serious complications.

Methods: We retrospectively reviewed the Korean nationwide population-based COVID-19 dataset for participants who underwent real-time reverse transcription polymerase chain reaction assays for COVID-19 between January 1 and June 4, 2020. A 1 : 3 ratio propensity score matching and binary logistic regression analysis were performed to investigate the association between AD and the susceptibility or severe complications (i.e., mechanical ventilation, intensive care unit admission, or death) of COVID-19.

Results: Among 195,643 study participants, 5,725 participants had AD and 7,334 participants were diagnosed with COVID-19. The prevalence of participants testing positive for COVID-19 did not differ according to the presence of AD (p = 0.234). Meanwhile, AD was associated with an increased risk of severe COVID-19 complications (OR 2.25 [95% CI 1.54-3.28]). Secondary outcome analyses showed that AD patients had an increased risk for mortality (OR 3.09 [95% CI 2.00-4.78]) but were less likely to receive mechanical ventilation (OR 0.42 [95% CI 0.20-0.87]).

Conclusion: AD was not associated with increased susceptibility to COVID-19 infection, but was associated with severe COVID-19 complications, especially with mortality. Early diagnosis and active intervention are necessary for patients with AD suspected COVID-19 infection.
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220031
DOI
10.3233/JAD-220031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188733
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