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Diagnostic accuracy of prostate-specific antigen below 4 ng/mL as a cutoff for diagnosing prostate cancer in a hospital setting: A systematic review and meta-analysis

Authors
 Yan Jin  ;  Jae Hung Jung  ;  Woong Kyu Han  ;  Eu Chang Hwang  ;  Yoonmi Nho  ;  Narae Lee  ;  Ji Eun Yun  ;  Kwang Suk Lee  ;  Sang Hyub Lee  ;  Hakmin Lee  ;  Su-Yeon Yu 
Citation
 INVESTIGATIVE AND CLINICAL UROLOGY, Vol.63(3) : 251-261, 2022-05 
Journal Title
INVESTIGATIVE AND CLINICAL UROLOGY
ISSN
 2466-0493 
Issue Date
2022-05
MeSH
Early Detection of Cancer ; Hospitals ; Humans ; Male ; Prostate-Specific Antigen* ; Prostatic Neoplasms* / diagnosis ; ROC Curve ; Sensitivity and Specificity
Keywords
Diagnosis ; Prostate-specific antigen ; Prostatic neoplasms
Abstract
Purpose: A prostate-specific antigen (PSA) cutoff of 4 ng/mL has been widely used for prostate cancer screening in population-based settings. However, the accuracy of PSA below 4 ng/mL as a cutoff for diagnosing prostate cancer in a hospital setting is inconclusive. We systematically reviewed the accuracy of PSA below 4 ng/mL cutoff in a hospital setting.

Materials and methods: We systematically reviewed the literature by searching major databases until March 2020, and a meta-analysis and quality assessment were performed.

Results: A total of 11 studies were included at the completion of the screening process. The meta-analysis showed a sensitivity of 0.92 and a specificity of 0.16 for a PSA cutoff below 4 ng/mL. The area under the hierarchical summary receiver operating characteristic curve was 0.87, the positive likelihood ratio was 1.23, the negative likelihood ratio was 0.46, and the diagnostic odds ratio was 2.64. PSA sensitivities and specificities varied according to the cutoff range: 0.94 and 0.17 for 2 to 2.99 ng/mL, and 0.92 and 0.16 for 3 to 3.99 ng/mL, respectively. No significant differences in the sensitivity and specificity of PSA cutoffs in the range of 2 to 2.99 ng/mL and 3 to 3.99 ng/mL were found.

Conclusions: Although a PSA cutoff <3 ng/mL is relatively more sensitive and specific than PSA ≥3 ng/mL, no significant differences in sensitivity and specificity were found in the diagnosis of prostate cancer. Therefore, clinicians should choose an appropriate PSA cutoff on the basis of clinical circumstances and patients' characteristics.
Files in This Item:
T202201833.pdf Download
DOI
10.4111/icu.20210429
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188718
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