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Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Authors
 Chang Kyung Kang  ;  Hyun Mu Shin  ;  Pyoeng Gyun Choe  ;  Jiyoung Park  ;  Jisu Hong  ;  Jung Seon Seo  ;  Yung Hie Lee  ;  Euijin Chang  ;  Nam Joong Kim  ;  Minji Kim  ;  Yong-Woo Kim  ;  Hang-Rae Kim  ;  Chang-Han Lee  ;  Jun-Young Seo  ;  Wan Beom Park  ;  Myoung-Don Oh 
Citation
 BMC MEDICINE, Vol.20(1) : 181, 2022-05 
Journal Title
BMC MEDICINE
Issue Date
2022-05
MeSH
Antibodies, Viral ; COVID-19 Testing ; COVID-19 Vaccines ; COVID-19* / prevention & control ; Humans ; Immunity, Cellular ; RNA, Messenger / genetics ; SARS-CoV-2* / genetics ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
Keywords
COVID-19 ; Immune response ; SARS-CoV-2 ; Vaccination ; mRNA
Abstract
Background: Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be given to unvaccinated patients who experienced COVID-19 early in the pandemic.

Methods: We recruited COVID-19 convalescent individuals who received one or two doses of an mRNA vaccine within 6 or around 18 months after a diagnosis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Their samples were assessed for IgG-binding or neutralizing activity and cell-mediated immune responses against SARS-CoV-2 wild-type and variants of concern.

Results: A total of 43 COVID-19 convalescent individuals were analyzed in the present study. The results showed that humoral and cellular immune responses against SARS-CoV-2 wild-type and variants of concern, including the Omicron variant, were comparable among patients vaccinated within 6 versus around 18 months. A second dose of vaccine did not significantly increase immune responses.

Conclusion: One dose of mRNA vaccine should be considered sufficient to elicit a broad immune response even around 18 months after a COVID-19 diagnosis.
Files in This Item:
T202201923.pdf Download
DOI
10.1186/s12916-022-02383-4
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Seo, Jun Young(서준영) ORCID logo https://orcid.org/0000-0003-4004-2013
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188680
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