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Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)

Authors
 Jong Cheol Jeong  ;  Tai Yeon Koo  ;  Han Ro  ;  Dong Ryeol Lee  ;  Dong Won Lee  ;  Jieun Oh  ;  Jayoun Kim  ;  Dong-Wan Chae  ;  Young Hoon Kim  ;  Kyu Ha Huh  ;  Jae Berm Park  ;  Yeong Hoon Kim  ;  Seungyeup Han  ;  Soo Jin Na Choi  ;  Sik Lee  ;  Sang-Il Min  ;  Jongwon Ha  ;  Myoung Soo Kim  ;  Curie Ahn  ;  Jaeseok Yang  ;  KOTRY Study Group 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 8706, 2022-05 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-05
MeSH
Graft Rejection ; Graft Survival* ; Humans ; Kidney Transplantation* ; Registries ; Republic of Korea / epidemiology ; Tissue Donors ; Treatment Outcome
Abstract
Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures.
Files in This Item:
T202202032.pdf Download
DOI
10.1038/s41598-022-12302-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Yang, Jaeseok(양재석)
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188636
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