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Cost-effectiveness of chronic hepatitis C screening and treatment

Authors
 Hye Won Lee  ;  Hankil Lee  ;  Beom Kyung Kim  ;  Young Chang  ;  Jae Young Jang  ;  Do Young Kim 
Citation
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.28(2) : 164-173, 2022-04 
Journal Title
CLINICAL AND MOLECULAR HEPATOLOGY
ISSN
 2287-2728 
Issue Date
2022-04
MeSH
Adult ; Antiviral Agents / therapeutic use ; Cost-Benefit Analysis ; Hepacivirus / genetics ; Hepatitis C* / drug therapy ; Hepatitis C, Chronic* / diagnosis ; Hepatitis C, Chronic* / drug therapy ; Humans
Keywords
Cost-effectiveness ; Hepatitis C ; Screening
Abstract
Hepatitis C virus (HCV) infection is the second most common cause of chronic liver disease in South Korea, with a prevalence ranging from 0.6% to 0.8%, and HCV infection incidence increases with age. The anti-HCV antibody test, which is cheaper than the HCV RNA assay, is widely used to screen for HCV infections; however, the underdiagnosis of HCV is a major barrier to the elimination of HCV infections. Although several risk factors have been associated with HCV infections, including intravenous drug use, blood transfusions, and hemodialysis, most patients with HCV infections present with no identifiable risk factors. Universal screening for HCV in adults has been suggested to improve the detection of HCV infections. We reviewed the cost-effectiveness of HCV screening and the methodologies used to perform screening. Recent studies have suggested that universal HCV screening and treatment using direct-acting antivirals represent cost-effective approaches to the prevention and treatment of HCV infection. However, the optimal timing and frequency of HCV screening remain unclear, and further studies are necessary to determine the best approaches for the elimination of HCV infections.
Files in This Item:
T202201502.pdf Download
DOI
10.3350/cmh.2021.0193
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188571
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