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Tenofovir is Associated With Higher Risk of Kidney Function Decline Than Entecavir in Patients With Chronic Hepatitis B

Authors
 Chan-Young Jung  ;  Hyung Woo Kim  ;  Sang Hoon Ahn  ;  Seung Up Kim  ;  Beom Seok Kim 
Citation
 CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol.20(4) : 956-958.e2, 2022-04 
Journal Title
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 1542-3565 
Issue Date
2022-04
MeSH
Antiviral Agents / adverse effects ; Guanine / adverse effects ; Guanine / analogs & derivatives ; Hepatitis B virus ; Hepatitis B, Chronic* / drug therapy ; Humans ; Kidney ; Retrospective Studies ; Tenofovir / adverse effects ; Treatment Outcome
Abstract
Of the antiviral agents currently available to patients with chronic hepatitis B (CHB), entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are 2 of 3 first-line agents.1-3 Given the well-known renal and bone toxicity associated with TDF,4 major international hepatitis B virus treatment guidelines recommend ETV over TDF in patients with predisposing factors to kidney function decline.1-3 However, as evidenced by recent studies, nephrotoxicity of antiviral agents is still an issue under debate.5-7 Therefore, we investigated the differences in the risk of kidney function decline in patients with treatment-naive CHB who were treated with ETV or TDF.
Full Text
https://www.sciencedirect.com/science/article/pii/S154235652100570X
DOI
10.1016/j.cgh.2021.05.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Jung, Chan-Young(정찬영) ORCID logo https://orcid.org/0000-0002-2893-9576
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188529
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