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Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer's Disease Study: BICWALZS

 Hyun Woong Roh  ;  Na-Rae Kim  ;  Dong-Gi Lee  ;  Jae-Youn Cheong  ;  Sang Won Seo  ;  Seong Hye Choi  ;  Eun-Joo Kim  ;  Soo Hyun Cho  ;  Byeong C Kim  ;  Seong Yoon Kim  ;  Eun Young Kim  ;  Jaerak Chang  ;  Sang Yoon Lee  ;  Dukyong Yoon  ;  Jin Wook Choi  ;  Young-Sil An  ;  Hee Young Kang  ;  Hyunjung Shin  ;  Bumhee Park  ;  Sang Joon Son  ;  Chang Hyung Hong 
 PSYCHIATRY INVESTIGATION, Vol.19(2) : 100-109, 2022-02 
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Alzheimer’s disease ; Cohort ; Dementia ; Mild cognitive impairment ; Subcortical vascular cognitive impairment ; Vascular dementia
Objective: We aimed to present the study design and baseline cross-sectional participant characteristics of biobank innovations for chronic cerebrovascular disease with Alzheimer's disease study (BICWALZS) participants.

Methods: A total of 1,013 participants were enrolled in BICWALZS from October 2016 to December 2020. All participants underwent clinical assessments, basic blood tests, and standardized neuropsychological tests (n=1,013). We performed brain magnetic resonance imaging (MRI, n=817), brain amyloid positron emission tomography (PET, n=713), single nucleotide polymorphism microarray chip (K-Chip, n=949), locomotor activity assessment (actigraphy, n=200), and patient-derived dermal fibroblast sampling (n=175) on a subset of participants.

Results: The mean age was 72.8 years, and 658 (65.0%) were females. Based on clinical assessments, total of 168, 534, 211, 80, and 20 had subjective cognitive decline, mild cognitive impairment (MCI), Alzheimer's dementia, vascular dementia, and other types of dementia or not otherwise specified, respectively. Based on neuroimaging biomarkers and cognition, 199, 159, 78, and 204 were cognitively normal (CN), Alzheimer's disease (AD)-related cognitive impairment, vascular cognitive impairment, and not otherwise specified due to mixed pathology (NOS). Each group exhibited many differences in various clinical, neuropsychological, and neuroimaging results at baseline. Baseline characteristics of BICWALZS participants in the MCI, AD, and vascular dementia groups were generally acceptable and consistent with 26 worldwide dementia cohorts and another independent AD cohort in Korea.

Conclusion: The BICWALZS is a prospective and longitudinal study assessing various clinical and biomarker characteristics in older adults with cognitive complaints. Details of the recruitment process, methodology, and baseline assessment results are described in this paper.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Dukyong(윤덕용)
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