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Therapeutic Efficacy of Spironolactone for Central Serous Chorioretinopathy

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dc.contributor.author김민-
dc.contributor.author김성수-
dc.contributor.author김용준-
dc.contributor.author변석호-
dc.contributor.author이승규-
dc.contributor.author이준원-
dc.contributor.author이지환-
dc.contributor.author최은영-
dc.contributor.author한재용-
dc.date.accessioned2022-05-09T17:10:26Z-
dc.date.available2022-05-09T17:10:26Z-
dc.date.issued2022-04-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188420-
dc.description.abstractPurpose: To evaluate the therapeutic effects and safety of oral spironolactone (SPRL) in patients with central serous chorioretinopathy (CSC). Materials and methods: The medical records and imaging data of patients diagnosed with CSC and treated with SPRL were retrospectively reviewed. Central macular thickness (CMT), subretinal fluid (SRF) height, subfoveal choroidal thickness (SFCT), and best-corrected visual acuity (BCVA) at baseline, at 1, 3, and 6 months, and at the last visit after the treatment were analyzed. Results: In total, 103 patients with 107 eyes were included. The mean age of the patients was 51.5±9.3 years, and 77 (72.0%) were male. The mean follow-up duration was 48.6±40.2 weeks. The mean duration of oral SPRL therapy was 15.5±13.4 weeks. CMT, SRF height, and SFCT improved significantly at 1, 3, and 6 months after SPRL therapy and at the last follow-up. BCVA, however, showed no significant change at any time point. The rate of complete resolution of SRF at 1 month was higher in those with chronic CSC than in those with acute CSC (21.1% vs. 6.0%, respectively). Recurrence occurred in 14 (13.1%) eyes after the complete resolution of SRF. Older age (p=0.001), a greater number of previous intravitreal bevacizumab injections (p=0.006), and poor initial visual acuity (p=0.048) were associated with recurrence. No permanent adverse effects were observed. Conclusion: Oral SPRL showed therapeutic benefits in patients with CSC in terms of SRF resolution, but relatively frequent recurrence was observed, especially in older patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCentral Serous Chorioretinopathy* / diagnosis-
dc.subject.MESHCentral Serous Chorioretinopathy* / drug therapy-
dc.subject.MESHFluorescein Angiography / methods-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSpironolactone* / therapeutic use-
dc.subject.MESHTomography, Optical Coherence / methods-
dc.subject.MESHVisual Acuity-
dc.titleTherapeutic Efficacy of Spironolactone for Central Serous Chorioretinopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorJae Yong Han-
dc.contributor.googleauthorYong Joon Kim-
dc.contributor.googleauthorEun Young Choi-
dc.contributor.googleauthorJunwon Lee-
dc.contributor.googleauthorJi Hwan Lee-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorSuk Ho Byeon-
dc.contributor.googleauthorSung Soo Kim-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.identifier.doi10.3349/ymj.2022.63.4.365-
dc.contributor.localIdA00455-
dc.contributor.localIdA00571-
dc.contributor.localIdA05821-
dc.contributor.localIdA01849-
dc.contributor.localIdA02913-
dc.contributor.localIdA03179-
dc.contributor.localIdA03222-
dc.contributor.localIdA05056-
dc.contributor.localIdA06142-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid35352888-
dc.subject.keywordCentral serous chorioretinopathy-
dc.subject.keywordspironolactone-
dc.subject.keywordtherapeutics-
dc.contributor.alternativeNameKim, Min-
dc.contributor.affiliatedAuthor김민-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor김용준-
dc.contributor.affiliatedAuthor변석호-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이준원-
dc.contributor.affiliatedAuthor이지환-
dc.contributor.affiliatedAuthor최은영-
dc.contributor.affiliatedAuthor한재용-
dc.citation.volume63-
dc.citation.number4-
dc.citation.startPage365-
dc.citation.endPage371-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.63(4) : 365-371, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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