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Low Incidence of Hepatocellular Carcinoma after Antiviral Therapy in Patients with Chronic Hepatitis C and Hemophilia

Authors
 In Jung Kim  ;  Sung Hwan Yoo  ;  Sora Kim  ;  Young Youn Cho  ;  Ki Young Yoo  ;  Hyung Joon Kim  ;  Hyun Woong Lee 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.11(5) : 1451, 2022-03 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2022-03
Keywords
chronic hepatitis C ; hemophilia ; hepatocellular carcinoma
Abstract
Background: Hepatocellular carcinoma (HCC) rarely develops in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). We assessed the incidence of HCC in CHC patients with hemophilia after treatment with pegylated interferon plus ribavirin (PegIFN/RBV) and direct-acting antivirals (DAAs).

Methods: Patients (n = 202) were enrolled between March 2007 and July 2019. A total of 139 patients were treated with PegIFN/RBV (genotype 1, n = 98; genotype 2, n = 41). Sixty-three patients were treated with DAAs (genotype 1, n = 44; genotype 2, n = 19). The cumulative incidence rates of HCC were estimated using the Kaplan-Meier method and compared using the log-rank test.

Results: For genotype 1, SVR was achieved in 78.6% (77/98) and 90.9% (40/44) of patients in the PegIFN/RBV and DAAs groups, respectively. For genotype 2, SVR was achieved in 95.1% (39/41) and 94.7% (18/19) of patients in the PegIFN/RBV and DAAs groups, respectively. Six HCC cases were identified. The cumulative incidence of HCC was 4.1% at 14 years in PegIFN/RBV and 1.7% at 5 years in DAAs. The 14-year cumulative incidence of HCC was 1.9% in the SVR group and 21.7% in the no-SVR group in the PegIFN/RBV group (p < 0.001).

Conclusions: Treatment with PegIFN/RBV led to stable SVR and a low incidence of HCC. Although the follow-up period was short, DAAs led to more stable SVR than PegIFN/RBV and a low incidence of HCC in CHC patients with hemophilia.
Files in This Item:
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DOI
10.3390/jcm11051451
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Ra(김소라)
Yoo, Sung Hwan(유성환)
Lee, Hyun Woong(이현웅) ORCID logo https://orcid.org/0000-0002-6958-3035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188396
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