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Long Non-Coding RNA-Based Functional Prediction Reveals Novel Targets in Notch-Upregulated Ovarian Cancer

Authors
 Seonhyang Jeong  ;  Sunmi Park  ;  Young Suk Jo  ;  Moon Jung Choi  ;  Gibbeum Lee  ;  Seul Gi Lee  ;  Min Chul Choi  ;  Hyun Park  ;  Won Duk Joo  ;  Sang Geun Jung  ;  Jandee Lee 
Citation
 CANCERS, Vol.14(3) : 1557, 2022-03 
Journal Title
CANCERS
Issue Date
2022-03
Keywords
DNA repair ; Notch ; long non-coding RNA ; ovarian cancer ; spermatogenesis
Abstract
Notch signaling is a druggable target in high-grade serous ovarian cancers; however, its complexity is not clearly understood. Recent revelations of the biological roles of lncRNAs have led to an increased interest in the oncogenic action of lncRNAs in various cancers. In this study, we performed in silico analyses using The Cancer Genome Atlas data to discover novel Notch-related lncRNAs and validated our transcriptome data via NOTCH1/3 silencing in serous ovarian cancer cells. The expression of novel Notch-related lncRNAs was down-regulated by a Notch inhibitor and was upregulated in high-grade serous ovarian cancers, compared to benign or borderline ovarian tumors. Functionally, Notch-related lncRNAs were tightly linked to Notch-related changes in diverse gene expressions. Notably, genes related to DNA repair and spermatogenesis showed specific correlations with Notch-related lncRNAs. Master transcription factors, including EGR1, CTCF, GABPα, and E2F4 might orchestrate the upregulation of Notch-related lncRNAs, along with the associated genes. The discovery of Notch-related lncRNAs significantly contributes to our understanding of the complex crosstalk of Notch signaling with other oncogenic pathways at the transcriptional level.
Files in This Item:
T202201042.pdf Download
DOI
10.3390/cancers14061557
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Jo, Young Suk(조영석) ORCID logo https://orcid.org/0000-0001-9926-8389
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188389
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