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Association between birth weight and neurodevelopmental disorders assessed using the Korean National Health Insurance Service claims data

 In Gyu Song  ;  Han-Suk Kim  ;  Yoon-Min Cho  ;  You-Na Lim  ;  Duk-Soo Moon  ;  Seung Han Shin  ;  Ee-Kyung Kim  ;  Joonsik Park  ;  Jeong Eun Shin  ;  Jungho Han  ;  Ho Seon Eun 
 SCIENTIFIC REPORTS, Vol.12(1) : 2080, 2022-02 
Journal Title
Issue Date
Attention Deficit Disorder with Hyperactivity / epidemiology* ; Autism Spectrum Disorder / epidemiology* ; Birth Weight / physiology* ; Child ; Child, Preschool ; Female ; Humans ; Male ; National Health Programs ; Neurodevelopmental Disorders / epidemiology* ; Republic of Korea / epidemiology ; Retrospective Studies ; Risk ; Risk Factors
The risk of neurodevelopmental disorders in low birth weight (LBW) infants has gained recognition but remains debatable. We investigated the risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-aged children according to their birth weight. We conducted a retrospective cohort study using the Korean National Health Insurance claims data of 2,143,652 children who were born between 2008 and 2012. Gestational age of infants was not available; thus, outcomes were not adjusted with it. Not only infants with birth weights of < 1.5 kg, but also 2.0-2.4 kg and 1.5-1.9 kg were associated with having ADHD; odds ratio (OR), 1.41 (95% confidence interval [CI] 1.33-1.50), and 1.49 (95% CI 1.33-1.66), respectively. The OR in infants with birth weights of 2.0-2.4 kg and 1.5-1.9 kg was 1.91 (95% CI 1.79-2.05) and 3.25 (95% CI 2.95-3.59), respectively, indicating increased odds of having ASD. Subgroup analysis for children without perinatal diseases showed similar results. In this national cohort, infants with birth weights of < 2.5 kg were associated with ADHD and ASD, regardless of perinatal history. Children born with LBW need detailed clinical follow-up.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joon Sik(박준식) ORCID logo https://orcid.org/0000-0002-4902-4770
Song, In Gyu(송인규) ORCID logo https://orcid.org/0000-0002-3205-9942
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Han, Jung Ho(한정호) ORCID logo https://orcid.org/0000-0001-6661-8127
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