0 55

Cited 0 times in

Combined tumor epithelial and stromal histopathology with keratin 81 expression predicts prognosis for pancreatic ductal adenocarcinoma

Authors
 Eunhyang Park  ;  Jeong Eun Yoo  ;  Ho Kyoung Hwang  ;  Chang Moo Kang  ;  Choong-Kun Lee  ;  Min Hwan Kim  ;  Seungmin Bang  ;  Young Nyun Park 
Citation
 JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Vol.29(2) : 250-261, 2022-02 
Journal Title
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
ISSN
 1868-6974 
Issue Date
2022-02
MeSH
Biomarkers, Tumor / genetics ; Carcinoma, Pancreatic Ductal* / genetics ; Carcinoma, Pancreatic Ductal* / pathology ; Humans ; Keratins / genetics ; Neoadjuvant Therapy ; Pancreatic Neoplasms* / genetics ; Pancreatic Neoplasms* / metabolism ; Pancreatic Neoplasms* / therapy ; Prognosis
Keywords
keratin 81 ; pancreatic ductal adenocarcinoma ; prognostic factor ; tumor epithelial histopathology ; α-smooth muscle actin
Abstract
Background: Development of a pragmatic pathologic classifier of pancreatic ductal adenocarcinoma (PDAC) that reflects biological behavior is needed.

Methods: The tumor epithelial and stromal features of PDAC and molecular subtype-related markers were evaluated in three independent cohorts.

Results: In the non-neoadjuvant therapy cohort (n = 108), regarding tumor-epithelial feature, non-gland-forming type showed worse prognosis compared to gland-forming type (P < .001). For tumor-stromal feature, in gland-forming type, the prognosis was good in order of inactivated stroma-rich, stroma-poor, and activated stroma-rich (P = .027). Whereas, non-gland-forming type revealed no difference of prognosis according to tumor stroma. Of molecular subtype-related markers, keratin 81 expression was correlated with non-gland-forming type and poor prognosis (P = .005 and P = .021, respectively). Other markers (HNF1A, c-MET, and p53) showed no significant differences in prognosis. In the neoadjuvant therapy cohort (n = 68), non-gland-forming type was correlated with high residual tumor volume (≥20%) (P < .001) and gland-forming/stroma-poor type was not present. In the next-generation sequencing cohort (n = 55), non-gland-forming type was correlated with a higher number of the KRAS, TP53, CDKN2A, and SMAD4 mutations (P = .038).

Conclusion: Combined tumor epithelial and stromal histopathology with keratin 81 expression is suggested to be useful for predicting prognosis of PDAC.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/jhbp.1025
DOI
10.1002/jhbp.1025
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Min Hwan(김민환) ORCID logo https://orcid.org/0000-0002-1595-6342
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Eunhyang(박은향) ORCID logo https://orcid.org/0000-0003-2658-5054
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Yoo, Jeong Eun(유정은)
Lee, Choong-kun(이충근) ORCID logo https://orcid.org/0000-0001-5151-5096
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188280
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links